Automated lesion placement in the rabbit eye

Abstract

Automated feedback control placement of argon laser lesions is possible at a reasonable cost and has numerous therapeutic and safety benefits over current ballistic delivery.

Laser Ophthalmology

“…They are using the reflectance from a forming therapeutic lesion as a visible marker of immeasurable lesion depth. They are also working on a seamless, clinically significant prototype to safely and quickly place therapeutic retinal lesions for the treatment of various disorders [65][66][67][68][69].…”

Laser Ophthalmology

“…They are using the reflectance from a forming therapeutic lesion as a visible marker of immeasurable lesion depth. They are also working on a seamless, clinically significant prototype to safely and quickly place therapeutic retinal lesions for the treatment of various disorders [65][66][67][68][69].…”

Efficiently tracking a moving object in two-dimensional image space

“…The tracking system measured retinal movement dynamically and derived laser position update information which thereby provided real-time, motion stabilized lesion placement. 1,5,[8][9][10] This system was adapted to assist the Optical Radiation Branch at Brooks AFB, TX, in establishing safe viewing eye standards for lasers.…”

“…This similarity measure proved to be robust and computationally simple. 5,6 For application 3, we summed the gray levels of the 3ϫ3 template array at each potential match location in the object image. The potential match location yielding the lowest sum was the position of the rat's head.…”

Computer-aided retinal photocoagulation system

“…The results of system development and initial testing have been reported elsewhere. [8][9][10][11][12][13][14][15][16][17] A brief review of the two subsystems with testing results is provided here.…”

“…Furthermore, the lesion placement subsystem was used to demonstrate the feasibility of placing lesions for the treatment of diabetic retinopathy and retinal tears in vivo on pigmented rabbits. 10,[14][15][16][17] Several in vivo experiments were accomplished to demonstrate lesion placement in a rectangular matrix pattern. This matrix pattern is of interest to researchers of lasertissue interaction studies.…”

Laser Ophthalmology

“…They are using the reflectance from a forming therapeutic lesion as a visible marker of immeasurable lesion depth. They are also working on a seamless, clinically significant prototype to safely and quickly place therapeutic retinal lesions for the treatment of various disorders [65][66][67][68][69].…”

Efficiently tracking a moving object in two-dimensional image space

“…The tracking system measured retinal movement dynamically and derived laser position update information which thereby provided real-time, motion stabilized lesion placement. 1,5,[8][9][10] This system was adapted to assist the Optical Radiation Branch at Brooks AFB, TX, in establishing safe viewing eye standards for lasers.…”

“…This similarity measure proved to be robust and computationally simple. 5,6 For application 3, we summed the gray levels of the 3ϫ3 template array at each potential match location in the object image. The potential match location yielding the lowest sum was the position of the rat's head.…”

Computer-aided retinal photocoagulation system

“…The results of system development and initial testing have been reported elsewhere. [8][9][10][11][12][13][14][15][16][17] A brief review of the two subsystems with testing results is provided here.…”

“…Furthermore, the lesion placement subsystem was used to demonstrate the feasibility of placing lesions for the treatment of diabetic retinopathy and retinal tears in vivo on pigmented rabbits. 10,[14][15][16][17] Several in vivo experiments were accomplished to demonstrate lesion placement in a rectangular matrix pattern. This matrix pattern is of interest to researchers of lasertissue interaction studies.…”

Laser Ophthalmology

“…They are using the reflectance from a forming therapeutic lesion as a visible marker of immeasurable lesion depth. They are also working on a seamless, clinically significant prototype to safely and quickly place therapeutic retinal lesions for the treatment of various disorders [65][66][67][68][69].…”

Efficiently tracking a moving object in two-dimensional image space

“…The tracking system measured retinal movement dynamically and derived laser position update information which thereby provided real-time, motion stabilized lesion placement. 1,5,[8][9][10] This system was adapted to assist the Optical Radiation Branch at Brooks AFB, TX, in establishing safe viewing eye standards for lasers.…”

“…This similarity measure proved to be robust and computationally simple. 5,6 For application 3, we summed the gray levels of the 3ϫ3 template array at each potential match location in the object image. The potential match location yielding the lowest sum was the position of the rat's head.…”

Computer-aided retinal photocoagulation system

“…The results of system development and initial testing have been reported elsewhere. [8][9][10][11][12][13][14][15][16][17] A brief review of the two subsystems with testing results is provided here.…”

“…Furthermore, the lesion placement subsystem was used to demonstrate the feasibility of placing lesions for the treatment of diabetic retinopathy and retinal tears in vivo on pigmented rabbits. 10,[14][15][16][17] Several in vivo experiments were accomplished to demonstrate lesion placement in a rectangular matrix pattern. This matrix pattern is of interest to researchers of lasertissue interaction studies.…”