2019
DOI: 10.1101/848218
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Abstract: AbstractObjectiveA major challenge in the care of preterm infants is the early identification of compromised neurological development. While several measures are routinely used to track anatomical growth, there is a striking lack of reliable and objective tools for tracking maturation of early brain function; a cornerstone of lifelong neurological health. We present a cot-side method for measuring the functional maturity of the newborn brain b… Show more

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Cited by 2 publications
(5 citation statements)
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“…21,24,25,32,35 This is supported by the findings of Stevenson et al, who showed that brain maturational delays in infants born extremely preterm in the neonatal phase, as indicated by the predicted age difference between true and predicted PCA derived from a support vector machine model, were related to long-term adverse outcomes. 39 The results of conventional EEG absolute power analyses were consistent with the findings of amplitudeintegrated EEG amplitude-related measures; in infants born extremely preterm, preterm, and at term, higher absolute power in several frequency bands was related to favourable long-term outcomes, as were higher amplitudeintegrated EEG amplitudes. 26,40 However, absolute amplitude values cannot be compared between the studies included in this review because different amplitudeintegrated EEG systems have different amplitude values.…”
Section: Discussionsupporting
confidence: 74%
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“…21,24,25,32,35 This is supported by the findings of Stevenson et al, who showed that brain maturational delays in infants born extremely preterm in the neonatal phase, as indicated by the predicted age difference between true and predicted PCA derived from a support vector machine model, were related to long-term adverse outcomes. 39 The results of conventional EEG absolute power analyses were consistent with the findings of amplitudeintegrated EEG amplitude-related measures; in infants born extremely preterm, preterm, and at term, higher absolute power in several frequency bands was related to favourable long-term outcomes, as were higher amplitudeintegrated EEG amplitudes. 26,40 However, absolute amplitude values cannot be compared between the studies included in this review because different amplitudeintegrated EEG systems have different amplitude values.…”
Section: Discussionsupporting
confidence: 74%
“…The findings by Stevenson et al delineate the value of serial EEGs since single-recording deviations of the developmental trajectory and overall changes in trajectories were revealed. 39 Serial EEGs increase the capacity to distinguish between transient and chronic EEG abnormalities. 69,70 Therefore, we recommend that future researchers should consider investigating serial EEG recordings.…”
Section: Discussionmentioning
confidence: 99%
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“…Though it is easy to perform EEG monitors on neonates lasting for hours or even days at the bedside, the raw EEG signal data are usually very large, which takes experienced neurophysiologists several hours to interpret. Besides, that neonates' brain is developing complicates the evaluation of EEG pattern (4), especially among preterm neonates (5). O'Reilly designed a new EEG signal feature range EEG (rEEG) in 26 newborns with less than 29 weeks of gestational age and found that it is closely related to brain development and maturity (6).…”
Section: Introductionmentioning
confidence: 99%
“…O'Reilly designed a new EEG signal feature range EEG (rEEG) in 26 newborns with less than 29 weeks of gestational age and found that it is closely related to brain development and maturity (6). Similarly, Stevenson et al constructed a brain age prediction model based on EEG signal features from 65 preterm infants, which could greatly fit actual age and the predicted age difference could be used as a predictor of the neurodevelopmental outcome (5,7,8). These studies are all tested on small data sets, and there is no systematic analysis on how to apply the findings to the clinic.…”
Section: Introductionmentioning
confidence: 99%