Automated Assessment of Quantitative REM Sleep without Atonia for Diagnosis of REM Sleep Behavior Disorder

Yang, Jae Mo; Choi, Sang Ho; Lee, Mi Hyun; Oh, Seong Min; Choi, Jae Won; Park, Jee Eun; Park, Kwang Suk; Lee, Yu Jin

doi:10.33069/cim.2020.0016

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Rapid eye movement sleep (REM) and non-rapid eye movement sleep (n-REM), which alternate throughout the night in a roughly 90-minute cycle. n-REM sleep is further divided into three stages (Figure 3) [126].…”

Section: Sleep Cyclementioning

confidence: 99%

Pathophysiology of Memory Inception and Retrogression and Clock Dependent Divergence in Cognizance

et al. 2021

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The body clock regulation is quite complex to describe in a simple manner. For instance, when the body is symbolized as a machine, that operates all of its staff in a synchronized way, continuously affected by the frame of time and light propensity. As a result, environmental factors such as light and darkness, as well as the body clock (endogenous circadian rhythms) work in unison to improve hemostasis, including the cell cycle, body temperature, feeding, metabolism, and, perhaps most importantly, the sleep-wake cycle as well as memory formation and consolidation [1].Physiological, biological, and behavioural processes in mammals are regulated by circadian rhythms. The endogenous biological clock is located in the suprachiasmatic nuclei (SCN), a small group of hypothalamic nerves, recognized as the master circadian pacemaker. It is positioned unswervingly above the op-

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Section: Sleep Cyclementioning

confidence: 99%

Pathophysiology of Memory Inception and Retrogression and Clock Dependent Divergence in Cognizance

et al. 2021

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Quantification of REM sleep without atonia: A review of study methods and meta-analysis of their performance for the diagnosis of RBD

Puligheddu

Figorilli

Congiu

et al. 2023

Sleep Medicine Reviews

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Comparison of rapid eye movement without atonia quantification methods to diagnose rapid eye movement sleep behavior disorder: a systematic review

Byun

Yang

Sunwoo

et al. 2022

Sleep

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Study Objective Rapid eye movement (REM) without atonia is essential for diagnosing REM sleep behavior disorder (RBD). Manual and automatic quantifications of REM without atonia (RWA) that use different criteria have been validated. This study compared the RWA quantification methods for diagnosing RBD. Methods The PubMed, EMBASE, Web of Science, and Cochrane Library databases were systemically searched for studies published from inception to December 2021. The inclusion criteria were cohort, cross-sectional and case–control studies assessing the sensitivity and specificity of RWA quantification methods. Pooled estimates of the sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) were determined. Risk of bias and certainty of evidence were assessed using the Quality Assessment of Diagnostic Accuracy Studies tool and the Grading of Recommendations, Assessment, Development and Evaluations framework, respectively. Results Fourteen articles including 402 RBD patients met the inclusion criteria. Manual methods evaluating any chin and phasic flexor digitorum superficialis (FDS) activity had the highest DOR (138.80, 95% CI: 21.849-881.72) and AUC (0.9686). The automatic REM atonia index (RAI) showed similar or higher sensitivity (89.1%, 95% CI: 84.6-92.7) but a lower specificity (73.5%), DOR (43.1) and AUC (0.9369) than the manual techniques. Conclusions In this meta-analysis, manual RWA quantification that employed chin or phasic FDS activity had the best RBD diagnostic performance. The automatic RAI method may be useful for screening RBD patients. The results should be interpreted carefully because of the high risk of bias in patient selection and significant heterogeneity among the studies.

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Automated Assessment of Quantitative REM Sleep without Atonia for Diagnosis of REM Sleep Behavior Disorder

Cited by 4 publications

References 23 publications

Pathophysiology of Memory Inception and Retrogression and Clock Dependent Divergence in Cognizance

Pathophysiology of Memory Inception and Retrogression and Clock Dependent Divergence in Cognizance

Quantification of REM sleep without atonia: A review of study methods and meta-analysis of their performance for the diagnosis of RBD

Comparison of rapid eye movement without atonia quantification methods to diagnose rapid eye movement sleep behavior disorder: a systematic review

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