Autologous Osteochondral Mosaicplasty

Hangody, László; Ráthonyi, Gábor K.; Duska, Zsófia; Vásárhelyi, Gábor; Fules, P J; Módis, László

doi:10.2106/00004623-200403001-00009

Cited by 128 publications

(50 citation statements)

References 2 publications

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“…A wide-range of non-specific symptoms may lead clinicians to consider that an AC defect is the source of a patient's pain, including locking, pain at rest, swelling, pain with activity, instability and retropatellar crepitus (16,17). Approximately, two-thirds of patients with chondral defects have associated ligamentous or meniscal pathology, and AC damage has been reported in association with 23% of anterior cruciate ligament (ACL) injuries and 54% of knees with chronic ACL laxity or instability (6).…”

Section: Patient Selection and Indication For Surgerymentioning

confidence: 99%

“…The first choice treatment for lesions < 2.5 cm 2 is bone marrow stimulation by microfracture (8,(22)(23)(24). Larger lesions may be treated by mosaicplasty (17); this technique is limited by the availability of donor tissue, or by autologous chondrocyte transplantation, which is becoming more widely available (8). Other treatments, such as abrasion chondroplasty and the use of carbon fibre pads, are either less widely practised, or have been superseded and are therefore not discussed.…”

Section: Current Treatment Optionsmentioning

confidence: 99%

“…Autologous osteochondral allografting, also known as mosaicplasty, most commonly involves transplantation of small (< 1 cm 2 ) cylindrical cartilage plugs harvested from non-weight bearing areas such as the lateral femoral condyle or the trochlea, directly into the defect in a one-stage procedure (17) (Figure 3). The use of different size plugs allows defect filling of more than 90%, and the graft needs to be perpendicular and flush to the surface to prevent catching with knee motion (17). This technique has the advantage of directly implanting hyaline cartilage onto the defect.…”

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

“…This technique has the advantage of directly implanting hyaline cartilage onto the defect. The procedure may be carried out open or arthroscopically and is not recommended in (17). Good to excellent results have been reported in 85-95% of treated defects of the femoral condyles, tibial surfaces and patellar ⁄ trochlear lesions (38)(39)(40)(41)(42)(43).…”

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

“…It is important to note that repair using autologous tissue technique is most suited to small (< 4 cm 2 ) lesions, being limited by the availability of donor tissue and by potential donor-site morbidity (17,44). Larger defects may be filled with allogenous cartilage tissue from a cadaveric donor, although this risks immunologic rejection and disease transmission from donor to recipient.…”

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

See 4 more Smart Citations

Current strategies for knee cartilage repair

Kalson¹,

Gikas²,

Briggs³

2010

International Journal of Clinical Practice

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Summary Defects in knee articular cartilage (AC) can cause pain and disability and present the clinician with an extremely challenging clinical situation. This article describes the most up‐to‐date surgical techniques that aim to repair and/or regenerate symptomatic focal defects in AC, which include arthroscopic debridement, microfracture bone marrow stimulation and autologous osteochondral allografting, with an emphasis on autologous chondrocyte implantation. In the future, refinement of tissue‐engineering approaches promises to further improve outcome for these patients.

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Section: Patient Selection and Indication For Surgerymentioning

confidence: 99%

Section: Current Treatment Optionsmentioning

confidence: 99%

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

Section: Autologous Osteochondral Grafting ⁄ Mosaicplastymentioning

confidence: 99%

See 3 more Smart Citations

Current strategies for knee cartilage repair

Kalson¹,

Gikas²,

Briggs³

2010

International Journal of Clinical Practice

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show abstract

Cartilage Injury and Repair

Li¹,

Wang²,

Liu³

et al. 2022

Biofabrication for Orthopedics

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Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

et al. 2023

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Cartilage degeneration is among the fundamental reasons behind disability and pain across the globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none have shown acceptable outcomes in the long run. In this regard, the convergence of tissue engineering and microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives to current treatments and traditional constructs used in tissue engineering applications. Herein, the current developments involving microfluidic hydrogel‐based scaffolds, promising structures for cartilage regeneration, ranging from hydrogels with microfluidic channels to hydrogels prepared by the microfluidic devices, that enable therapeutic delivery of cells, drugs, and growth factors, as well as cartilage‐related organ‐on‐chips are reviewed. Thereafter, cartilage anatomy and types of damages, and present treatment options are briefly overviewed. Various hydrogels are introduced, and the advantages of microfluidic hydrogel‐based scaffolds over traditional hydrogels are thoroughly discussed. Furthermore, available technologies for fabricating microfluidic hydrogel‐based scaffolds and microfluidic chips are presented. The preclinical and clinical applications of microfluidic hydrogel‐based scaffolds in cartilage regeneration and the development of cartilage‐related microfluidic chips over time are further explained. The current developments, recent key challenges, and attractive prospects that should be considered so as to develop microfluidic systems in cartilage repair are highlighted.

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Autologous Osteochondral Mosaicplasty

Cited by 128 publications

References 2 publications

Current strategies for knee cartilage repair

Current strategies for knee cartilage repair

Cartilage Injury and Repair

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

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