Autoimmunity in Pernicious Anæmia and Iron-Deficiency Anæmia

Autoimmune serological studies in chronic gastritis and pernicious anaemia

“…The finding in the present study of a complementfixing autoantibody to a gastric mucosal antigen in the serum of patients with pernicious anaemia is in keeping with the findings of Irvine, Davies, Delamore, and , Markson and Moore (1962a), and Taylor and co-workers (1962). Moreover, our finding of a similar incidence of positive reactions in chronic gastritis and pernicious anaemia is consistent with the generally held view that the gastric lesion of pernicious anaemia is merely a late stage of a slowly evolving chronic gastritis.…”

“…The clinical and pathological evidence linking pernicious anaemia and thyroiditis is substantiated by the serological overlap between the two conditions. First, there is a significantly raised incidence of anti-thyroid antibodies in pernicious anaemia, figures of 240%, 37 %, and 31 % being obtained by Markson and Moore (1962b), Irvine and co-workers (1962), and in this study respectively. Secondly there is a correspondingly increased incidence of antibodies to gastric mucosa in Hashimoto's thyroiditis, as shown by Irvine's group (1962) and by Markson and Moore (1962a).…”

Immunological disturbances in myasthenia gravis with a report of Hashimoto's disease developing after thymectomy

“…The other patients with pernicious anaemia listed in the full series (Table I) are no longer available for immunological studies. It has also been reported recently that pernicious anaemia may be associated with rheumatoid arthritis (Partridge and Duthie, 1963), with autoimmune thyroiditis (Irvine et al, 1962;Taylor et al, 1962;Markson and Moore, 1962), with thyrotoxicosis and systemic lupus erythematosus (Doniach, Roitt, and Taylor, 1963), and with diabetes mellitus (Arapakis, Bock, Williams, and Witts, 1963;Beckett and Matthews, 1962). There is thus an overlap between several diseases associated with abnormal immunological reactions and to these myasthenia gravis should now be added.…”

On Immunologically Induced Gastric Atrophy in Dogs

“…A num ber of studies in the past few years point to the participation of immunological mechanisms in hum an chronic gastritis and pernicious anaemia [5,6,12]. Antibodies to constituents of gastric mucosa have been dem onstrated in the serum of some patients with pernicious anaemia and also of some patients with chronic gastritis w ithout pernicious anaemia.…”