1993
DOI: 10.1002/eji.1830231143
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Abstract: We have reported that, in A/J (A) (H-2a) mice, a partial tolerance to C57BL/10ScSn (B10) (H-2b) skin allografts and a high incidence of lethal lymphoproliferative disorders (LPD) can be induced by the neonatal i.v. injection of 2 x 10(7) semiallogeneic (B10 x A)F1 spleen cells (SC) (Végh, P., Baranyi, L. and Jánossy, T., Cell. Immunol. 1990, 129: 56). In this study, we show that the incidence and mortality of LPD were continuously growing from 1 month of age until the end of the experiment at 1 year (64% and 3… Show more

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Cited by 3 publications
(2 citation statements)
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“…Spleen cell subpopulations of both the nonnal and the ATS-pretreated donor animals were analysed by flow cytofluorometry. The monoclonal (anti-CD4, clone H129.19; anti-CD8, clone 53-6.72) and the FITClabelled antibodies (FITC-labelled goat anti-mouse Ig, Central Laboratory of Blood Transfusion Service, Amsterdam, The Netherlands; FITC-labelled anti-rat Ig, Sigma, St Louis, MO, USA; FITClabelled anti-rabbit IgG, Miles Scientific, Naperville, IL, USA), the immunofluorescent labelling, the immunofluorescent microscopy and the flow cytofluorometric analysis were described elsewhere [10].…”
Section: Methodsmentioning
confidence: 99%
“…Spleen cell subpopulations of both the nonnal and the ATS-pretreated donor animals were analysed by flow cytofluorometry. The monoclonal (anti-CD4, clone H129.19; anti-CD8, clone 53-6.72) and the FITClabelled antibodies (FITC-labelled goat anti-mouse Ig, Central Laboratory of Blood Transfusion Service, Amsterdam, The Netherlands; FITC-labelled anti-rat Ig, Sigma, St Louis, MO, USA; FITClabelled anti-rabbit IgG, Miles Scientific, Naperville, IL, USA), the immunofluorescent labelling, the immunofluorescent microscopy and the flow cytofluorometric analysis were described elsewhere [10].…”
Section: Methodsmentioning
confidence: 99%
“…Janossy et al [35][36][37] reported an increased frequency of lymphomas in mice following induction of neonatal tolerance. Tumors were of recipient origin, and analysis of two separate lymphomas revealed a T-cell origin in both [36].…”
Section: Lymphomas Following Transfer Of Allogeneic Hematopoietic Celmentioning
confidence: 99%