Autoimmune thyroid disease in Egyptian patients with rheumatoid arthritis

Saqre, Israa M.; El-Bahnasawy, Amany S.; Farag, Seif El-Dein M.; Bazeed, Fagr B.

doi:10.1016/j.ejr.2018.08.002

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…Twenty-nine studies met the inclusion criteria, involving 35,708 RA patients and 149,421 non-RA controls. Among them, 15 studies ( 5 , 11 , 13 , 22 , 24 , 25 , 27 , 31 , 33 , 34 ) provided ( 37 – 40 , 45 ) prevalence values for hyperthyroidism, 12 provided ( 5 , 11 , 22 , 24 , 31 , 33 , 34 , 36 , 37 , 42 , 44 , 45 ) prevalence values for subclinical hyperthyroidism, 26 provided ( 5 , 11 , 13 , 14 , 22 – 31 , 33 – 41 , 43 , 45 , 46 ) prevalence values for hypothyroidism, and 17 provided ( 5 , 11 , 14 , 22 , 24 , 31 – 34 , 36 – 39 , 42 – 45 ) prevalence values for subclinical hypothyroidism. The NOS checklist was used to evaluate the quality of studies, and 7 studies (24.13%) assessed as high quality, and 18 studies (62.07%) identified as medium quality.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies ( 5 , 11 , 13 , 22 , 24 , 25 , 27 , 31 ) recorded the prevalence of hyperthyroidism in RA and control groups ( 33 , 34 , 37 – 40 , 45 ). However, in 5 literatures ( 27 , 31 , 33 , 34 , 45 ), there is no information on hyperthyroidism in RA patients or controls.…”

Section: Resultsmentioning

confidence: 99%

“…After excluding two studies ( 31 , 44 ), in which subclinical hyperthyroidism was not found in any subjects, the prevalence of subclinical hyperthyroidism in RA patients and controls was calculated in a total of 10 studies ( 5 , 11 , 22 , 24 , 33 , 34 , 36 , 37 , 42 , 45 ) ( Figure 2B ). The pooled OR was 2.13 (95%CI 1.25–3.63) (P < 0.05), indicating that RA patients had more than twice the risk of subclinical hyperthyroidism as non-RA subjects, which was statistically significant.…”

Section: Resultsmentioning

confidence: 99%

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Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

et al. 2022

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ObjectiveRheumatoid arthritis (RA) is an autoimmune disorder. Multiple studies have investigated the risk of thyroid dysfunction in patients with RA but have reached conflicting conclusions. This systematic review aimed to determine whether patients with RA are at higher risk of thyroid dysfunction.MethodsWe comprehensively reviewed online literature databases, including PubMed, Scopus, Embase, and the Cochrane Library, from their respective inception dates to March 25, 2022. Studies that provided data on at least one case of thyroid dysfunction in RA patients and their controls were included. Based on these data, we calculated pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) for thyroid dysfunction in RA and non-RA patients.ResultsTwenty-nine studies met the inclusion criteria, involving a total of 35,708 patients with RA. The meta-analysis showed that, compared with non-RA patients, RA patients had an increased risk of developing thyroid dysfunction, particularly hypothyroidism (OR 2.25, 95% CI 1.78–2.84). Subgroup analysis suggested that study type and sample source of control group were the source of heterogeneity.ConclusionsPatients with RA are at increased risk of developing thyroid dysfunction, especially hypothyroidism. Routine biochemical examination of thyroid function in RA patients should be strengthened. Larger prospective studies are needed to explore the causal relationship between RA and thyroid dysfunction, and to investigate the impact of thyroid dysfunction on RA disease activity, drug efficacy, and medication safety.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022331142.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

et al. 2022

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“…It should also be mentioned that several studies only consider overt hypothyroidism and did not include the subclinical stage in their evaluation, yet some studies included both stages. In most of these studies, overt hypothyroidism was the most common thyroid dysfunction [ 11 , 25 – 27 ]; however, several of them showed subclinical hypothyroidism as the most common one [ 17 ] while others found no significant difference between subgroups [ 28 ]. We concluded in this study that RA only associated with overt hypothyroidism, 2.3 times more common among RA patients than controls, and no significant association between RA and subclinical form was observed.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis

et al. 2022

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Background Rheumatoid arthritis (RA) is one of the most common chronic non-organ-specific autoimmune diseases; meanwhile, autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease that can lead to hypo or hyperthyroidism. Although the etiology of both diseases is complex with a combination of genetic and environmental factors, there are overlaps in genes contributing to the pathogenesis of both diseases. Numerous studies found a correlation between thyroid abnormality and RA in different populations, yet some didn’t. This study is aimed to evaluate the prevalence of thyroid dysfunction, AITD, and anti-thyroid peroxidase (anti-TPO) positively in Iranian patients with RA. Methods A total of 250 RA patients and 248 patients with non-inflammatory rheumatologic disease were included in this case–control study. All participants underwent complete clinical and laboratory assessments. Participants were also assessed for thyroid function testing, including anti-TPO antibodies. Results Thyroid dysfunction was twice as common in RA patients as in controls (OR = 2.16; P-value > 0.001). Overt hypothyroidism was the most common thyroid dysfunction among RA patients (58 out of 84). Anti-TPO positivity was also significantly more common in RA compared with controls (OR = 2.65; P-value > 0.001). The proportion of controls and RA patients with AITD were 9 and 21.5%, respectively. AITD was found 2.8 times more common in RA group than controls (OR = 2.77; P-value > 0.001). Conclusion It was demonstrated that RA was an independent factor associated with thyroid dysfunction and AITD.

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“…Fayed et al (2019) reported thyroid disorder was related mainly to thyroid autoimmunity independent of age, sex, or HCV level of viremia. Saqre et al (2019) reported that autoimmune thyroiditis was frequent among young female patients with rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Challenge Thyroidectomy Manual Delivery Versus Sternotomy in Retrosternal Goiter

Sayed¹,

Shafik

IBRAHIM

2020

Journal of the Egyptian Society of Parasitology

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Autoimmune thyroid disease in Egyptian patients with rheumatoid arthritis

Cited by 9 publications

References 34 publications

Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis

Challenge Thyroidectomy Manual Delivery Versus Sternotomy in Retrosternal Goiter

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