Autogenous Platelet-Rich Plasma in Combination With Bovine-Derived Hydroxyapatite Xenograft for Treatment of a Cystic Lesion of the Jaw

Abstract

In the last 5 years, many studies about autogenous platelet-rich plasma have been undertaken pointing out its regenerative and reparative properties on tissues. The features of this product are an attribute of platelet cells, which, after cellular interactions, release growth factors. These molecules promote tissue healing and also induce cellular regeneration. Bone is a dynamic tissue subject to balanced processes of bony formation and reabsorption; autologous platelet gel or concentrate (PRP) can be used alone or in association with bony graft for the treatment of bony defect, cystic lesions, alveolar bone defects, and periodontal pockets. Its application fields are oral and maxillofacial surgery, plastic surgery, and general surgery, and it can be applied particularly in patients with coagulation diseases. In our experience, a giant cystic lesion of the jaw was treated with PRP and granules of bovine-derived hydroxyapatite xenograft to enhance bony regeneration and promote tissue healing.

A review on endogenous regenerative technology in periodontal regenerative medicine

“…However, findings have demonstrated that the gel-like material formed in cell cultures of either PDL or osteoblastic MG63 cells is a fibrin clot that is capable of up-regulating collagen synthesis in the extracellular matrix [146]. Analysis of data published to date suggests the possibility that fibrinogen, converted to fibrin, in combination with GFs present in PRP, or sometimes used as an adjuvant to osteoconductive biomaterials, might effectively promote wound healing at tbe site of injury in periodontal tissue [131,147,148]. This concept led to the development of advanced PRP-like scaffolds in different medical fields [27].…”

“…Such scaffold is known to induce cell attachment and spreading through its cell-binding site and related synergy sites [147]. Therefore, it is not difficult to presume that PRP-like scaffolds could potentially be used in ERT by inducing cell homing for in situ tissue regeneration.…”

Bone regeneration with plasma-rich-protein following enucleation of traumatic bone cyst

“…The secreted growth factors immediately bind to their transmembrane receptors on adult mesenchymal stem cells, osteoblasts, fibroblasts, epithelial cells and then cause cellular proliferation, matrix formation, osteoid production, and collagen synthesis through cellular message transforming. [293031] PRP also contain three proteins in blood known to act as cell adhesion molecules for osteoconduction and as a matrix for bone and connective tissue. These molecules are fibrinogen, fibronectin, and vitronectin.…”

The Role of Platelet Gel in Regenerative Medicine

“…The supernatant or releasate of the platelet gel was able to promote dose-dependent proliferation and changes in gene expression as well as in metabolic activities related to protein synthesis (Junger et al, 2000;Valencia et al, 2001;Fang & Galiano, 2008;Bernuzzi et al, 2010;Ficarelli et al, 2008;Chen et al, 2010). The platelet concentrate was used for healing skin, soft tissue wounds, fractures, surgical injuries, diabetic ulcers, dental, oral and maxillofacial settings (Altman et al, 2001;Margolis et al, 2001;Anderson &Baker, 2003;Castro, 2004;Belli et al, 2005;Burkus, 2005;Carreon et al, 2005;Sclafani et al, 2005;Trowbridge et al, 2005;Brown et al, 2006;Driver et al, 2006;Savarino et al, 2006;Rozman & Bolta, 2007;Borzini & Mazzucco 2007;Smrke et al, 2007;Cieslik-Bielecka et al, 2008;).…”