2004
DOI: 10.1089/1076327041348284
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Abstract: We have attempted to regenerate bone in a significant osseous defect with minimal invasiveness and good plasticity, and to provide a clinical alternative to autogenous bone grafts. Platelet-rich plasma (PRP) may enhance the formation of new bone and is nontoxic, nonimmunoreactive, and accelerates existing wound-healing pathways. We have used a combination of PRP as an autologous scaffold with in vitro-expanded mesenchymal stem cells (MSCs) to increase osteogenesis, compared with using the scaffold alone or aut… Show more

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Cited by 281 publications
(215 citation statements)
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“…Yamada et al [52] demonstrated in dogs that the combination of MSC and PLG resulted in a significantly higher maturation of bone and neovasularization than observed in control subjects. Thereafter, the same group used a combination of MSC and PLG for successful clinical alveolar bone augmentation [47].…”
Section: Tissue Engineeringmentioning
confidence: 99%
“…Yamada et al [52] demonstrated in dogs that the combination of MSC and PLG resulted in a significantly higher maturation of bone and neovasularization than observed in control subjects. Thereafter, the same group used a combination of MSC and PLG for successful clinical alveolar bone augmentation [47].…”
Section: Tissue Engineeringmentioning
confidence: 99%
“…The growth factors from the platelet-rich plasma, which can be used in a clinical setting, have been shown to positively affect the proliferation of MSCs (Lucarelli et al, 2003) and are thought to play a role in their osteogenic differentiation (Intini, 2009). When combined with biomaterials and cells, platelet-rich plasma has also been shown to promote bone formation in heterotopic sites (Bi et al, 2010;Kasten et al, 2008;Yamada et al, 2004). Studies to determine the time required to culture the MSCs as aggregates in order to optimise the amount of bone formed in vivo are performed so as to make the system more clinically feasible.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the addition of platelet-rich plasma (PRP), which includes various growth factors (Marx et al, 1988) and offers osteoinductive properties (Kanno et al, 2005), contributes to cellular proliferation, matrix formation, collagen synthesis, osteoid production, and other processes that accelerate tissue regeneration. In terms of using these autologous materials, tissue engineering for bone regeneration has been shown to be an attractive alternative to autogenous or synthetic bone substitutes (Ito et al, 2006;Yamada et al, 2004;Buser et al, 1990). It has the additional advantage of using the host as a donor source, which avoids bone graft donor site morbidity.…”
Section: Discussionmentioning
confidence: 99%