2012
DOI: 10.1084/jem.20111424
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Abstract: Autocrine VEGFR2 signaling in glioma stem-like cells evades VEGF neutralization.

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Cited by 349 publications
(265 citation statements)
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References 71 publications
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“…Interestingly, VEGFR2 is already implicated in tumorigenicity and stemness. 32,36 These data together demonstrate that, VEGFR2 is clearly linked to blebbishield-mediated sphere formation and tumorigenesis.…”
Section: Resultsmentioning
confidence: 71%
“…Interestingly, VEGFR2 is already implicated in tumorigenicity and stemness. 32,36 These data together demonstrate that, VEGFR2 is clearly linked to blebbishield-mediated sphere formation and tumorigenesis.…”
Section: Resultsmentioning
confidence: 71%
“…2 Targeting key kinases activated by DNA damage and involved in checkpoint activation, Chk1 and Chk2, with a small molecule inhibitor radiosensitizes GICs. 2 Further studies have provided additional molecular mechanisms of GIC radioresistance, including SirT1, 14 Notch, 15 STAT3, 16 VEGF/VEGFR2, 17 BMI1, 18 L1CAM, 19 and peroxiredoxin-1. 20 Altogether, these studies highlight a radioresistance phenotype for GICs, a potential direct contribution to tumor recurrence, and the prospect of targeting these cells through inhibition of molecular targets including the DDR.…”
mentioning
confidence: 99%
“…In that respect, expression of vascular endothelial growth factor-A (VEGF-A) was shown to be induced by hypoxia in most cell types [13,23], both in vitro and in vivo [24]. The VEGF family consists of the four homodimeric members VEGF-A, VEGF-B, VEGF-C and VEGF-D that bind and activate three corresponding VEGF receptors (VEGFR-1, VEGFR-2 and VEGFR-3), which are expressed by endothelial cells and many tumor types [25,26]. Under hypoxic conditions, tumor cells secrete enhanced levels of VEGF family members in a paracrine fashion to stimulate proliferation and migration of endothelial cells, thereby promoting tumor-associated angiogenesis.…”
Section: Induction Of Rtk Ligandsmentioning
confidence: 99%