Autoantigen 1 of the guinea pig sperm acrosome is the homologue of mouse Tpx-1 and human TPX1 and is a member of the cysteine-rich secretory protein (CRISP) family

Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix

“…Structurally and functionally, the acrosome consists of soluble and particulate compartments. Some of the proteins described as constituents of the soluble compartment are hyaluronidase, dipeptidyl peptidase, and CRISP2 (also known as autoantigen 1 or Tpx1) (Foster and Gerton, 1996;Hardy et al, 1991). The proteins of the particulate compartment or acrosomal matrix have been studied most extensively in the guinea pig and include proacrosin, AM50 (also known as p50, apexin, Narp, and neuronal pentraxin II), AM67 (the orthologue of mouse sperm protein ZP3R; previously known as sp56), and proacrosin-binding protein (Baba et al, 1994b;Honda et al, 2002;Noland et al, 1994).…”

Identification of a novel GPI‐anchored CRISP glycoprotein, MAK248, located on the posterior head and equatorial segment of cynomolgus macaque sperm

“…Antibodies to CRISP 1 are reported to interfere with sperm-oocyte fusion, thereby inhibiting fertility (Perez et al, 1995;Ellerman et al, 1998;Cohen et al, 2001). CRISP 2, TPX-1, is expressed in the testes and is not found on the sperm surface (Kasahara et al, 1989;Foster and Gerton, 1996;Keah et al, 2001;O'Bryan et al, 2001). Our data suggest that MAK248 is a CRISP protein and a member of the CAP super family.…”

Discovery and validation of novel biomarkers for detection of cervical cancer

“…During the progression of cervical cancer, from normal cervical tissues to CIN 1, 2 and 3, the gradually down‐regulated genes we confirmed were CRISP3, CRISP2, PPP1R3C, and DSG1. CRISP2 (gene ID: 7180) also belonging to the CRISP family, is strongly expressed in male reproductive tissues, including the testis, prostate and epididymis, 31 mediating the adhesion between cells and cells, and participate in the fertilization process together with CRISP1, 32 and spermatogenesis, modulation of flagellar motility, acrosome reaction and gamete fusion 33 . Those results suggested that the decrease in CRISP2 expression may lead to decreased sperm motility.…”