2007
DOI: 10.1111/j.1440-1843.2007.01140.x
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Autoantibody to alanyl‐tRNA synthetase in patients with idiopathic pulmonary fibrosis

Abstract: A significant number of IPF patients possess circulating autoantibodies against alanyl-tRNA synthetase, suggesting the involvement of an autoimmune background in the pathogenesis of IPF.

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Cited by 26 publications
(15 citation statements)
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“…ARS syndrome patients characteristically present with one or more of the following: Raynaud's phenomenon, fever, non-erosive inflammatory arthritis and hyperkeratotic skin changes on the fingers (‘mechanic's hands’). Lung involvement is particularly common in ARS syndromes, affecting up to 90% of patients regardless of their specific autoantibody 1 2. Lung involvement can be the initial manifestation of an ARS syndrome, and ARS syndrome can present in patients without myositis.…”
Section: Introductionmentioning
confidence: 99%
“…ARS syndrome patients characteristically present with one or more of the following: Raynaud's phenomenon, fever, non-erosive inflammatory arthritis and hyperkeratotic skin changes on the fingers (‘mechanic's hands’). Lung involvement is particularly common in ARS syndromes, affecting up to 90% of patients regardless of their specific autoantibody 1 2. Lung involvement can be the initial manifestation of an ARS syndrome, and ARS syndrome can present in patients without myositis.…”
Section: Introductionmentioning
confidence: 99%
“…The majority of IPF patients have IgG autoantibodies against various autoantigens that are typically distinct from those described in classical autoimmune syndromes (e.g., SLE, scleroderma, etc.) [5][6][7][8]9,14], and the presence of particular autoantibody responses in individual IPF patients have been associated with clinical manifestations of their lung disease [4,5,9]. In addition, T-cells among IPF patients show increased extents of prior activation, enhanced production of various inflammatory and/or pro-fibrotic mediators (e.g., TGF-b1), and impaired regulatory (T reg ) function [10][11][12][13][14]17].…”
Section: Discussionmentioning
confidence: 99%
“…Given the apparent prominence of CD4 T-cell responses in IPF [4][5][6][7][8][9][14][15][16][17], we were singularly interested in evaluating the HLA Class II allele frequencies of these patients, since CD4 lymphocytes are predominantly HLA Class IIdependent [25]. Findings of HLA allele biases in IPF could have significant implications for the role of immunogenetic mechanisms in the pathogenesis of this disease.…”
Section: Introductionmentioning
confidence: 99%
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“…Indeed, elevated levels of immune complexes have been reported in the blood and the lungs of patients with IPF [10,11,12,13,14,15,16]. It is therefore anticipated that pro-inflammatory interactions between immune complexes and leukocyte Fcγ receptors, like FcγRIIIb, would constitute an additional determinant for disease pathogenesis.…”
Section: Introductionmentioning
confidence: 99%