Autoantibodies in Neurodegenerative Diseases: Antigen-Specific Frequencies and Intrathecal Analysis

Terryberry, Jeff; Thor, G. Theander; Peter, James B.

doi:10.1016/s0197-4580(98)00049-9

Cited by 95 publications

(75 citation statements)

References 124 publications

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“…The observations presented here suggest that additional studies are needed on neural damage and/or axonal demyelinization in symptomatic Gulf War veterans. Neural antigen and MBP antibodies have been reported in patients with neurologic disorders (Terryberry et al 1998;Willison and Yuki 2002), including ALS (Rogers et al 1996), autism (Vojdani et al 2002), and multiple sclerosis (Vojdani et al 2003). Therefore, our results are consistent with the excess of ALS among Gulf War veterans reported by Haley (2003).…”

Section: Discussionsupporting

confidence: 90%

Cellular and humoral immune abnormalities in Gulf War veterans.

Vojdani

Thrasher

2004

Environ Health Perspect

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Section: Discussionsupporting

confidence: 90%

Cellular and humoral immune abnormalities in Gulf War veterans.

Vojdani

Thrasher

2004

Environ Health Perspect

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“…Serum anti-MBP Abs in MS patients have been reported before [42,[47][48], though not in all studies [49][50][51] patients analyzed by us demonstrated significantly higher levels of serum anti-MBP Abs than healthy individuals.…”

Section: Resultsmentioning

confidence: 43%

Hydrolysis of myelin basic protein by polyclonal catalytic IgGs from the sera of patients with multiple sclerosis

Polosukhina¹,

Kanyshkova²,

Доронин³

et al. 2004

J Cellular Molecular Medi

117

406

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Catalytically active artificial and natural antibodies (Abs) or abzymes (Abzs) have been studied intensively (see reviews [1][2][3][4][5][6][7]). The first example of a natural Abz was an IgG found in bronchial asthma patients which hydrolyzes intestinal vasoactive peptide (VIP) [8], the second was an IgG with DNase activity in SLE [9], and the third was an IgG with RNase activity in SLE [10].Catalytic IgGs and/or IgMs hydrolyzing RNA and DNA [9][10][11][12][13][14][15][16][17], polysaccharides [18][19] or peptides and proteins [20][21][22][23][24][25] AbstractVarious catalytic antibodies or abzymes have been detected recently in the sera of patients with several autoimmune pathologies, where their presence is most probably associated with autoimmunization. Recently we have shown that DNase, RNase, and polysaccharide-hydrolyzing activities are associated with IgGs from the sera of patients with multiple sclerosis (MS). Here we present evidence demonstrating that highly purified MS IgGs (but not Igs from the sera of healthy individuals) catalyze specifically hydrolysis of human myelin basic protein (hMBP). In contrast to many known proteases, IgGs do not hydrolyze many other different proteins. Specific inhibitors of acidic and thiol proteases have no remarkable effect on proteolytic activity of IgGs. However, specific inhibitor of serine (PMSF, AEBSF, and benzamidin) and metal-dependent (EDTA) proteases significantly inhibit activity of proteolytic abzymes. Interestingly, the ratio of serine-like and metal-dependent activities of MS IgGs varied very much from patient to patient. The findings speak in favor of the generation by the immune systems of individual MS patients of a variety of polyclonal anti-MBP IgGs with different catalytic properties.

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“…The occurrence of autoantibodies to several proteins has been reported in MS [5,6,14,15]. Using immunoblot analysis, we showed that sera of MS patients contain antibodies to various soluble retAgs and that 3 of them, p48, p46, and p41, were recognized more frequently than others.…”

Section: Discussionmentioning

confidence: 67%

Retinal Antigens Are Recognized by Antibodies Present in Sera of Patients with Multiple Sclerosis

et al. 2004

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Multiple sclerosis (MS) is frequently accompanied by visual symptoms including those related to retinal disorders. Since they may be a consequence of an autoimmune reaction, we examined whether sera of patients with diagnosed MS and changes in visual-evoked potentials contain antibodies against retinal antigens (retAgs). Immunoblot analysis revealed that MS sera recognized mainly a 46-kD antigen, a 41-kD antigen, retinal arrestin, to a smaller extent also 70-, 56-, 43-, and 36-kD proteins. Patients whose sera showed the highest reactivity with 41- and 46-kD antigens had deficiencies in visual acuity, visual fields, ophthalmoscopy, and electroretinograms. Our observation suggests that antibodies to these retAgs may play a role in the origin of ophthalmologic impairment in MS.

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Autoantibodies in Neurodegenerative Diseases: Antigen-Specific Frequencies and Intrathecal Analysis

Cited by 95 publications

References 124 publications

Cellular and humoral immune abnormalities in Gulf War veterans.

Cellular and humoral immune abnormalities in Gulf War veterans.

Hydrolysis of myelin basic protein by polyclonal catalytic IgGs from the sera of patients with multiple sclerosis

Retinal Antigens Are Recognized by Antibodies Present in Sera of Patients with Multiple Sclerosis

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