Autoantibodies Against Constituents of Neutrophils in the Diagnosis and Treatment of (Isolated) Subglottic Stenosis

Severe tracheobronchial stenosis in a patient with Crohn's disease

“…The absence of cutaneous pustules excluded a diagnosis of Sweet's syndrome [18]. Tracheobronchial involvement in Wegener's granulomatosis may present as ulcerating tracheobronchitis or tracheal/bronchial stenosis [19,20]. The extent of tracheal and bronchial lesions observed in the current patient, the absence of histological findings suggestive of Wegener's granulomatosis, the lack of cytoplasmic-antineutrophil cytoplasmic antibodies (c-ANCA), no extrapulmonary involvement and slow progression without specific treatment all made, in the authors' opinion, the diagnosis of Wegener's granulomatosis unlikely.…”

Severe tracheobronchial stenosis in a patient with Crohn's disease

“…The absence of cutaneous pustules excluded a diagnosis of Sweet's syndrome [18]. Tracheobronchial involvement in Wegener's granulomatosis may present as ulcerating tracheobronchitis or tracheal/bronchial stenosis [19,20]. The extent of tracheal and bronchial lesions observed in the current patient, the absence of histological findings suggestive of Wegener's granulomatosis, the lack of cytoplasmic-antineutrophil cytoplasmic antibodies (c-ANCA), no extrapulmonary involvement and slow progression without specific treatment all made, in the authors' opinion, the diagnosis of Wegener's granulomatosis unlikely.…”

Patterns of airway involvement in inflammatory bowel diseases

“…The ANCA type specificity and histology of the airway lesions may help differentiate IBD-related UAD from GPA. Interestingly, isolated ANCA positivity without vasculitis has been associated with isolated subglottic stenosis in one study [48] . Empirical data suggest initial treatment with systemically administered high doses of corticosteroids (prednisone 1 mg/kg of lean body weight administered orally or methylprednisolone 60-80 mg intravenously per day); these suggestions are drawn from case reports, however, and not from randomized controlled trials, and should therefore be critically viewed [3] .…”

Idiopathic laryngotracheal stenosis: Effective definitive treatment with laryngotracheal resection

“…Antineutrophil cytoplasm antibody test results were reviewed. 10,11 Patients with other known causes of subglottic stenosis were excluded from the study.…”

Severe tracheobronchial stenosis in a patient with Crohn's disease

“…The absence of cutaneous pustules excluded a diagnosis of Sweet's syndrome [18]. Tracheobronchial involvement in Wegener's granulomatosis may present as ulcerating tracheobronchitis or tracheal/bronchial stenosis [19,20]. The extent of tracheal and bronchial lesions observed in the current patient, the absence of histological findings suggestive of Wegener's granulomatosis, the lack of cytoplasmic-antineutrophil cytoplasmic antibodies (c-ANCA), no extrapulmonary involvement and slow progression without specific treatment all made, in the authors' opinion, the diagnosis of Wegener's granulomatosis unlikely.…”

Patterns of airway involvement in inflammatory bowel diseases

“…The ANCA type specificity and histology of the airway lesions may help differentiate IBD-related UAD from GPA. Interestingly, isolated ANCA positivity without vasculitis has been associated with isolated subglottic stenosis in one study [48] . Empirical data suggest initial treatment with systemically administered high doses of corticosteroids (prednisone 1 mg/kg of lean body weight administered orally or methylprednisolone 60-80 mg intravenously per day); these suggestions are drawn from case reports, however, and not from randomized controlled trials, and should therefore be critically viewed [3] .…”

Idiopathic laryngotracheal stenosis: Effective definitive treatment with laryngotracheal resection

“…Antineutrophil cytoplasm antibody test results were reviewed. 10,11 Patients with other known causes of subglottic stenosis were excluded from the study.…”

Severe tracheobronchial stenosis in a patient with Crohn's disease

“…The absence of cutaneous pustules excluded a diagnosis of Sweet's syndrome [18]. Tracheobronchial involvement in Wegener's granulomatosis may present as ulcerating tracheobronchitis or tracheal/bronchial stenosis [19,20]. The extent of tracheal and bronchial lesions observed in the current patient, the absence of histological findings suggestive of Wegener's granulomatosis, the lack of cytoplasmic-antineutrophil cytoplasmic antibodies (c-ANCA), no extrapulmonary involvement and slow progression without specific treatment all made, in the authors' opinion, the diagnosis of Wegener's granulomatosis unlikely.…”

Patterns of airway involvement in inflammatory bowel diseases

“…The ANCA type specificity and histology of the airway lesions may help differentiate IBD-related UAD from GPA. Interestingly, isolated ANCA positivity without vasculitis has been associated with isolated subglottic stenosis in one study [48] . Empirical data suggest initial treatment with systemically administered high doses of corticosteroids (prednisone 1 mg/kg of lean body weight administered orally or methylprednisolone 60-80 mg intravenously per day); these suggestions are drawn from case reports, however, and not from randomized controlled trials, and should therefore be critically viewed [3] .…”

Idiopathic laryngotracheal stenosis: Effective definitive treatment with laryngotracheal resection

“…Antineutrophil cytoplasm antibody test results were reviewed. 10,11 Patients with other known causes of subglottic stenosis were excluded from the study.…”