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Pharmacogenetics of statin intolerance

“…3 A recent meta-analysis suggests that the caution regarding simvastatin dosing in the presence of this variant also applies to rosuvastatin. 5 Examination of Pharmaceutical Benefits Scheme for the year 2018 showed that simvastatin and rosuvastatin accounted for 18% and 29% (respectively) of all statins dispensed in Australia (http://medicarestatistics.humanservices.gov. au/statistics/pbs_item.jsp).…”

“…While the SLCO1B1 gene is by far the most robustly associated variant with SAMS, an increasing array of genetic variants is also reported to be associated with SAMS phenotypes. 5 A predisposing genetic polymorphism will increase the risk of an event, such as SAMS, but the vast majority of people with a high-risk polymorphism will still not develop the event. 6 Conversely, people without a highrisk polymorphism may still develop the condition.…”

“…4 The definition of euthanasia is a 'deliberate intervention undertaken with the express intention of ending a life, to relieve intractable suffering'. 5 In the Act, voluntary-assisted dying (VAD) is, therefore, an umbrella term that includes both actions. Under the Act, the first action perfectly fits the definition of PAS; the second, the definition of euthanasia.…”

Differences in susceptibility of HT‐29 and A549 cells to statin‐induced toxicity: An investigation using high content screening

“…[11,12] Although statins are generally well tolerated with relatively few adverse reactions, and their clinical application and research scope have expanded accordingly, [13] statin-induced toxic side effects are an emerging concern. [14] Hepatotoxicity and myotoxicity are the most common severe adverse reactions to statins in the clinical setting, although the mechanisms of these toxicities are not well understood. [15,16] Interestingly, statins have been found to be toxic to many cells examined in vitro, including brain, lung, intestinal, C2C12, H9c2, and liver cells.…”