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Cited by 5 publications
(7 citation statements)
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References 7 publications
(7 reference statements)
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“…This is noteworthy since these cell lines, which do not have BRCA1/BRCA2 mutation, are generally not responsive to the alternative PARP inhibition therapies. Although combining PARP inhibitors with AL could potentially be efficacious based on the suggestion that inhibition of AAK mimics “BRCAness” ( 30 ), our preliminary results (data not shown) examining the combination of AL and olaparib in PEO4 HGSOC cells with wild type BRCA ( 18 ) did not lead to potentiation of cytotoxicity. At best, an additive effect was observed.…”
Section: Discussionmentioning
confidence: 81%
“…This is noteworthy since these cell lines, which do not have BRCA1/BRCA2 mutation, are generally not responsive to the alternative PARP inhibition therapies. Although combining PARP inhibitors with AL could potentially be efficacious based on the suggestion that inhibition of AAK mimics “BRCAness” ( 30 ), our preliminary results (data not shown) examining the combination of AL and olaparib in PEO4 HGSOC cells with wild type BRCA ( 18 ) did not lead to potentiation of cytotoxicity. At best, an additive effect was observed.…”
Section: Discussionmentioning
confidence: 81%
“…AURKA is a crucial regulator of cytokinesis, and its overexpression can cause centrosome amplification and abnormalities in spindle formation, resulting in tumor cell aneuploidy and chromosomal instability ( 21 ). It is a research target for the treatment of head and neck squamous cell carcinoma (HNSCC) through the signaling pathway of AURKA /Akt/focal adhesion kinase (FAK), which activates FAK and promotes the migration and invasion of HNSCC cells ( 22 ).…”
Section: Discussionmentioning
confidence: 99%
“…The functions of AURKA in regulating mitosis, spindle composition and centrosome have been well researched [ 37 ]. In addition, studies have reported that AURKA from the serine/threonine kinase family was overexpressed in various cancers and can be used as a prognostic marker for breast cancer and advanced serous ovarian cancer [ 38 , 39 ].…”
Section: Discussionmentioning
confidence: 99%