Augmentation of Wound Healing by Royal Jelly (RJ) in Streptozotocin-Diabetic Rats

Fujii, Akira; Kobayashi, Satoru; Kuboyama, Noboru; Furukawa, Yôko; Kaneko, Y; Ishihama, Seimi; Yamamoto, Hirotugu; Tamura, Toyoyuki

doi:10.1254/jjp.53.331

Cited by 119 publications

(76 citation statements)

References 11 publications

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“…Commercial RJ is obtained by harvesting the brood food from the queen cell in the 3rd day of larval development (ISO 12824:2016). (Fujii et al, 1990;Kohno et al, 2004), immunoregulatory (Okamoto et al, 2003;Vucevic et al, 2007), insulin-like (Dixit and Patel, 1964;Kramer et al, 1982), estrogen signaling mediating (Moutsatsou et al, 2010), antiaging (Inoue et al, 2003), reducing cholesterol levels (Kashima et al, 2014), vasodilation (Tokunaga et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Mărgăoan¹,

Mărghitaș²,

Dezmirean³

et al. 2017

BUASVMCN-ASB

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Given their beneficial effects in terms of health, the natural products, especially beehive products, have drawn the attention of consumers since long time ago. In order to guarantee the quality of these products on the market, their chemical composition needs to be analyzed. Thus, this current research had as objective the establishment of quality parameters for beehive brood food derived products: apilarnil and queen bee larvae triturate. These two products were compared with royal jelly which is the basis of brood food in the first 3 days of larval stage. The carbohydrates were determined by HPLC-IR and allowed the identification of seven carbohydrate compounds, predominantly glucose, fructose and sucrose. The lipid profile was analyzed by the Soxhlet method. The total protein content was determined by the Kjeldahl method. Free amino acids were analyzed by LC-MS. A total of 31 amino acids were identified of which nine are essential amino acids for humans.

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Section: Introductionmentioning

confidence: 99%

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Mărgăoan¹,

Mărghitaș²,

Dezmirean³

et al. 2017

BUASVMCN-ASB

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“…Previous studies have demonstrated a wide range of health benefits to humans and model organisms, including vasodilative and hypotensive activities (Tokunaga et al, 2004), antitumor (Tamura et al, 1987), anti-inflammatory (Fujii et al, 1990;Kohno et al, 2004), antibacterial and disinfectant properties (Fujiwara et al, 1990;Shen et al, 2010a), antifatigue activity (Kamakura et al, 2001a), and increasing the average lifespan in mice (Inoue et al, 2003) and nematodes (Honda et al, 2011). Because of its great potential benefits to human health, RJ is widely used as a key component in many commercial products including medicine, dietary supplements, and cosmetics (Kamakura et al, 2001c).…”

Section: Introductionmentioning

confidence: 99%

Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody

Shen

Wang

Zhai

et al. 2015

J. Zhejiang Univ. Sci. B

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Major royal jelly protein 1 (MRJP1), designated apalbumin 1, has been regarded as a freshness marker of royal jelly (RJ). A MRJP1-specific peptide (IKEALPHVPIFD) identified by bioinformatics analysis of homologous members of the major royal protein family was synthesized and used to raise polyclonal anti-MRJP1 antibody (anti-SP-MRJP1 antibody). Western blot analysis showed that anti-SP-MRJP1 antibody only reacted with MRJP1 in RJ. In contrast, the previously reported antibody against recombinant MRJP1 (anti-R-MRJP1 antibody) reacted with other members of MRJP family in RJ. Enzyme-linked immunosorbent assay (ELISA) using anti-SP-MRJP1 antibody demonstrated that MRJP1 content in RJ stored at 40 °C significantly degraded by 37.3%, 55.9%, 58.0%, 60.6%, 65.7%, 72.7%, and 73.1% at 7, 14, 21, 28, 35, 42, and 49 d, respectively, when compared with MRJP1 content in fresh RJ (0 d). Optical density analysis of MRJP bands from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles demonstrated that the degradation of MRJP1, MRJP2, MRJP3, and MRJP5 in RJ was strongly and positively correlated with the period of storage (P<0.0001). Our results indicated anti-SP-MRJP1 antibody was highly specific for MRJP1, and ELISA using the antibody is a sensitive and easy-to-use method to determine the freshness and authenticity of RJ.

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“…For instance, RJ exhibits immunomodulatory properties (3,22,24) and inhibits the development of atoptic dermatitis-like skin lesions (26). Earlier we found that RJ had the ability to induce neurites from cultured rat pheochromocytoma PC12 cells (10), which prompted us to test the effects of RJ and its components on NSCs cultured from the central nervous system (CNS).…”

mentioning

confidence: 99%

Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro

et al. 2007

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Neural stem/progenitor cells (NSCs) proliferate vigorously as neurospheres in medium containing basic fibroblast growth factor (FGF-2), but start differentiating into neurons, astrocytes or oligodendrocytes in FGF-2-free medium. An extract of royal jelly (RJ) significantly increased the percentage in the total cell population of not only neurons immunoreactive for class III β-tubulin (Tuj1) but also astrocytes immunoreactive for glial fibrillary acidic protein (GFAP), and oligodendrocytes immunoreactive for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) generated from NSCs, but decreased that of nestin-positive NSCs. These results highlight a novel and outstanding property of the RJ, i.e., that it facilitates the differentiation of all types of brain cells (neurons, astrocytes, and oligodendrocytes). On the other hand, 10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid characteristic of RJ, increased the generation of neurons and decreased that of astrocytes from NSCs. These observations suggest that RJ contains plural components that differently influence neuronal and/or glial lineages and that HDEA is one of such components of RJ that facilitates neurogenesis by NSCs.

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Augmentation of Wound Healing by Royal Jelly (RJ) in Streptozotocin-Diabetic Rats

Cited by 119 publications

References 11 publications

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody

Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro

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