Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia

Gökdoğan, Çağıl; Genç, Aydan; Gülbahar, Özlem; Gökdoğan, Ozan; Helvaci, Ayşe; Bezgin, Selin Üstün; Memış, Leyla

doi:10.1016/j.bjorl.2015.10.008

Cited by 4 publications

(4 citation statements)

References 25 publications

(38 reference statements)

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“…Modelling neonatal hyperbilirubinaemia in animals has been approached in a number of ways. The injection of bilirubin alone is adequate to induce mild auditory damage in the guinea pig (Ye et al, 2012) and rat (Gokdogan et al, 2016). However, in order to model the more severe damage seen in affected children, accompanying the bilirubin with sulphonamide-based compounds such as sulfadimethoxine ('sulfa') has been an effective strategy in mice (Schiavon et al, 2018), rats (Karplus et al, 1988) and Rhesus monkeys (Ahlfors et al, 1986).…”

Section: Neonatal Jaundicementioning

confidence: 99%

The use of animal models to study cell transplantation in neuropathic hearing loss

Abbas

Rivolta

2019

Hearing Research

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Auditory neuropathy (AN) is a form of sensorineural deafness specifically affecting the conduction of the nerve impulse from the cochlear hair cells to the auditory centres of the brain. As such, the condition is a potential clinical target for 'cell replacement therapy', in which a functioning auditory nerve is regenerated by transplanting an appropriated neural progenitor. In this review, we survey the current literature and examine possible experimental models for this condition, with particular reference to their compatibility as suitable hosts for transplantation. The use of exogenous neurotoxic agents such as ouabain or β-bungarotoxin is discussed, as are ageing and noise-induced synaptopathy models. Lesioning of the nerve by mechanical damage during surgery and the neuropathy resulting from infectious diseases may be very relevant clinically, and we discuss whether there are good models for these situations. We also address genetic models for AN, examining whether the phenotypes truly model the clinical situation in their human counterpart syndromes-we use the example of the hyperbilirubinaemic Gunn rat as a particular instance in this regard.

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Section: Neonatal Jaundicementioning

confidence: 99%

The use of animal models to study cell transplantation in neuropathic hearing loss

Abbas

Rivolta

2019

Hearing Research

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“…[8] Pathological jaundice, which can develop between 24 h and 2 weeks after birth, must be treated immediately, otherwise it can cause hearing impairment or develop into nuclear jaundice, which can lead to cerebral palsy or death. [10][11][12][13][14][15] In newborns, pathological jaundice treatment is carried out using various methods including phototherapy, drug administration, and exchange transfusion. [16][17][18] Phototherapy with blue light wavelengths of 450 to 490 nm have been used in clinical practice for neonatal hyperbilirubinemia for ≈60 years.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics

et al. 2022

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Neonatal jaundice is a very common disease in newborns and can lead to brain damage or death in severe cases. Phototherapy with light‐emitting diode (LED) arrays is widely used as the easiest and fastest way to relieve jaundice in newborns, but it has distinct disadvantages such as loss of water in the patient, damage to the retina, and separation from parents. In this paper, a novel light source‐based phototherapy for neonatal jaundice is proposed using a textile‐based wearable organic light‐emitting diode (OLED) platform that can move flexibly and conform to the curvature of the human body. The soft and flexible textile‐based blue OLED platform is designed to have a peak wavelength of 470 nm, suitable for jaundice treatment, and shows performance (>20 µW cm−2 nm−1) suitable for intensive jaundice treatment even at low voltage (<4.0 V). The textile‐based OLEDs fabricated in this study exhibit an operating reliability of over 100 h and low‐temperature operation (<35 °C). The results of an in vitro jaundice treatment test using a large‐area blue OLED confirm that the bilirubin level decreases to 12 mg dL−1 with 3 h of OLED irradiation.

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“…Dentre as disfunções metabólicas que acometem o recém-nascido (RN), a elevada concentração sérica e não fisiológica de bilirrubina (BL) é de grande importância, devido à alta incidência e por se tratar de uma situação clínica potencialmente grave em neonatos (1)(2) . Níveis elevados de BL podem estar relacionados ao aumento eritrocitário associado à imaturidade hepática do RN, resultando no desequilíbrio entre a produção e a conjugação da BL.…”

Section: Introductionunclassified

Importância Do Diagnóstico Laboratorial Da Hiperbilirrubinemia Em Neonatos: Revisão De Literatura

Souza

Silva

Souza

et al. 2020

BJD

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Discutir a importância do diagnóstico laboratorial da hiperbilirrubinemia neonatal, bem como reconhecer sua influência para o acompanhamento clínico dos Recém Nascidos. Nesse contexto, realizou-se uma revisão de literatura para explorar a hiperbilirrubinemia e os aspectos relacionados ao diagnóstico laboratorial. Métdos: A pesquisa foi baseada no levantamento de artigos científicos publicados entre os anos 2013 à 2018 nas bases Scielo, PubMed e Bireme. Resultados e Discussão: Identificaram-se 16 artigos que atenderam aos critérios de inclusão, oito com abordagem qualitativa e oito estudos quantitativos. Observou-se que o nível sérico de BL total é uma ferramenta indispensável para o acompanhamento e identificação de possíveis casos de encefalopatia bilirrubínica, incluindo kernicterus em RN ictéricos. Constatou-se que o desenvolvimento de técnicas não-invasivas, como o método de determinação de BL transcutânea, tornou mais fácil o acompanhamento dos níveis de BL, com vantagem sobre repetidas coletas de sangue que representam risco de infecção para os RN, especialmente os prematuros. Conclusão: A partir dessa revisão integrativa da literatura foi possível confirmar a necessidade de novos métodos, que possam aferir de forma confiável o nível de BL, com menor custo e complexidade técnica, facilitando o diagnóstico de hiperbilirrubinemia e o acompanhamento dos neonatos ictéricos.

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Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia

Abstract: Hyperbilirubinemia of newborn rats may result both in sensory neural hearing loss and auditory neuropathy spectrum disorder.

Cited by 4 publications

References 25 publications

The use of animal models to study cell transplantation in neuropathic hearing loss

The use of animal models to study cell transplantation in neuropathic hearing loss

Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics

Importância Do Diagnóstico Laboratorial Da Hiperbilirrubinemia Em Neonatos: Revisão De Literatura

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