Auditory complications in childhood cancer survivors: A report from the childhood cancer survivor study

Whelan, Kimberly; Stratton, Kayla; Kawashima, Toana; Leisenring, Wendy; Hayashi, Susan S.; Waterbor, John W.; Blatt, Julie; Sklar, Charles A.; Packer, Roger J.; Mitby, Pauline; Robison, Leslie L.; Mertens, Ann C.

doi:10.1002/pbc.23025

Cited by 51 publications

(73 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Radiation therapy also increases the risk of ototoxicity, and survivors >5 years after diagnosis remain at risk for the development of ototoxicity. 12,19 We found that 6 patients had a 5-year progression of hearing loss, and 4 of them had received radiation for head lesions. Fortythree percent patients with hearing loss (ZBrock grade1) also exhibited hearing loss at low frequencies that were not defined in the Brock criteria.…”

Section: Discussionmentioning

confidence: 92%

Cisplatin-induced Hearing Loss

Yasui

Adachi

Kato

et al. 2014

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Cisplatin is an effective chemotherapeutic agent against pediatric cancers; however, ototoxicity is a concern. This study describes the frequency, severity, and clinical course of hearing loss in Japanese pediatric patients treated with cisplatin-based multimodal therapy. A total of 55 children who received cisplatin-based therapy from 1983 to 2012 underwent audiologic evaluations. Data were analyzed to determine the onset, time-to-progression, and severity of hearing loss. Thirty-five patients, 12 of 16 older patients (4 y or older), and 23 of 39 younger patients (under 4 y), including 7 of 8 patients treated with cisplatin, carboplatin, and radiotherapy, developed hearing loss. Ten of 18 patients who received a cumulative cisplatin dose of <360 mg/m developed hearing loss at a minimum dose of 200 mg/m. Median time to onset after the last cisplatin dose was 71 days; 6 patients developed hearing loss after ≥2 years. Four patients required hearing aids, 6 patients developed progressive hearing loss with time, and 4 patients exhibited persistent hearing failure at low frequencies. Risk factors for acquired hearing loss and its severity may be associated with a combination of factors such as cisplatin and carboplatin therapy, radiotherapy, age at diagnosis, and genetic background. Our results suggested that all pediatric patients treated with cisplatin would have their hearing evaluated regularly, irrespective of the cumulative cisplatin dose as a suggestion, and that further prospective studies regarding ototoxicity including genetic polymorphisms analysis were required.

show abstract

Section: Discussionmentioning

confidence: 92%

Cisplatin-induced Hearing Loss

Yasui

Adachi

Kato

et al. 2014

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

“…Especially when young children are seriously ill, their cooperation and attention may be reduced, which can lead to hearing test results that have poor reliability, and to overall low testing rates . In all cases, though, audiological monitoring for several years after cancer treatment is important as hearing loss may only appear many years later particularly for patients treated with cranial radiation …”

Section: Discussionmentioning

confidence: 99%

Audiological monitoring in Swiss childhood cancer patients

Weiß

Kuonen

Brockmeier

et al. 2017

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. [5,6] and it was observed that patients who had hearing loss primarily had bilateral symmetric sensorineural hearing loss [7]. Moreover, one recent systematic review has also indicated that patients receiving radiotherapy for head and neck tumors could be at risk of developing sensorineural hearing loss, although high-quality research is still lacking [8].…”

Section: Main Findingsmentioning

confidence: 95%

Chronic diseases and life events accounted for 2–18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007

Ivy¹

2015

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

show abstract

Auditory complications in childhood cancer survivors: A report from the childhood cancer survivor study

Abstract: Background-Studies have found associations between cancer therapies and auditory complications, but data are limited on long-term outcomes and risks associated with multiple exposures.

Cited by 51 publications

References 42 publications

Cisplatin-induced Hearing Loss

Cisplatin-induced Hearing Loss

Audiological monitoring in Swiss childhood cancer patients

Chronic diseases and life events accounted for 2–18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007

Contact Info

Product

Resources

About