Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy

Wang, Man; Chang, Mengyu; Chen, Qing; Wang, Dongmei; Li, Chunxia; Hou, Zhiyao; Lin, Jun; Jin, Dayong; Xing, Bengang

doi:10.1016/j.biomaterials.2020.120093

Cited by 235 publications

(174 citation statements)

References 96 publications

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“…3,36 Increasing the decomposition of H 2 O 2 in TME by various nanomaterials would increase the therapeutic effect of treating tumors with phototherapy, chemodynamic therapy, and radiotherapy. 37,38 In vitro Enhanced Radiotherapy…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects

Yang¹,

Han²,

Chen³

et al. 2021

IJN

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Background: Radiotherapy occupies an essential position as one of the most significant approaches for the clinical treatment of cancer. However, we cannot overcome the shortcoming of X-rays which is the high value of the oxygen enhancement ratio (OER). Radiosensitizers with the ability to enhance the radiosensitivity of tumor cells provide an alternative to changing X-rays to protons and heavy ion radiotherapy. Materials and Methods: We prepared the Au-Pt nanoparticles (Au-Pt NPs) using a onestep method. The characteristics of the Au-Pt NPs were determined using TEM, HAADF-STEM, elemental mapping images, and DLS. The enhanced radiotherapy was demonstrated in vitro using MTT assays, colony formation assays, fluorescence imaging, and flow cytometric analyses of the apoptosis. The biodistribution of the Au-Pt NPs was analyzed using ICP-OES, and thermal images. The enhanced radiotherapy was demonstrated in vitro using immunofluorescence images, tumor volume and weigh, and hematoxylin & eosin (H&E) staining. Results: Polyethylene glycol (PEG) functionalized nanoparticles composed of the metallic elements Au and Pt were designed to increase synergistic radiosensitivity. The mechanism demonstrated that heavy metal NPs possess a high X-ray photon capture crosssection and Compton scattering effect which increased DNA damage. Furthermore, the Au-Pt NPs exhibited enzyme-mimicking activities by catalyzing the decomposition of endogenous H 2 O 2 to O 2 in the solid tumor microenvironment (TME). Conclusion: Our work provides a systematically administered radiosensitizer that can selectively reside in a tumor via the EPR effect and enhances the efficiency of treating cancer with radiotherapy.

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Section: Synthesis and Characterizationmentioning

confidence: 99%

Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects

Yang¹,

Han²,

Chen³

et al. 2021

IJN

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“…Considered as one of the most practical imaging techniques in clinic, CT distinguishes diverse tissues in light of X‐ray attenuation degrees (Skotland, Iversen, & Sandvig, 2010). In the first example, Au 2 Pt nanozymes possessing catalase‐/peroxidase‐mimics activities alongside strong absorption in NIR region and Ce6 (a second‐generation photosensitizer) were integrated into a system for superior PTT/CDT/PDT (M. Wang, Chang, et al, 2020). In the meantime, the outstanding X‐ray attenuation ability of Au and Pt elements in this system provided great opportunities to achieve CT (Figure 6g).…”

Section: Design Of Nanomedicine For Ptt/cdtmentioning

confidence: 99%

Section: Design Of Nanomedicine For Ptt/cdtmentioning

confidence: 99%

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

Yao

Fang

Yao

et al. 2020

WIREs Nanomed Nanobiotechnol

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Given the diversity, complexity, and heterogeneity of persistent tumors, traditional nanoscale monotherapeutic systems suffer from dissatisfactory curative efficiency with incidence of metastasis or relapse. In parallel, the trend of clinical research on the basis of nanomedicines has increasingly shifted from monotherapy toward combinatorial therapy for admirable synergetic performances. In this regard, cutting‐edge nanomedicines harnessing photothermal‐chemodynamic bimodal therapy (PTT/CDT) have opened up a highly‐efficient and relatively‐safe cancer theranostic paradigm. Still, the integration of PTT/CDT functional units into one nanomedicine remains a herculean but meaningful task to achieve notable super‐additive effects. This review aims to elucidate underlying synergistic interactions of PTT/CDT and highlight intriguing designs of nanomedicines for PTT/CDT including nanomaterial selection, performance optimization, multimodal therapy, visualization strategies, and targeting strategies. Furthermore, an outlook on further improvements of PTT/CDT is provided, emphasizing significant scientific issues that require remediation for clinical translation. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…[ 4 ] Thus, innovative and effective cancer treatments with remarkably improved therapeutic effects and reduced side effects are urgently needed. [ 5–7 ] Hyperthermia therapy (HTT), a treatment where the targeted tumor sites reach temperatures within a range of 41–48 °C, has been applied as an adjuvant cancer treatment strategy to improve the therapeutic effect of chemoradiotherapy. [ 8 ] More importantly, hyperthermia therapy has a direct cancer cell killing effect.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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Figure 3. a) Schematic illustration of the PTT-assisted immunotherapy. b) PD-L1 expression on 4T1 tumor cells after different treatments. c) Flow cytometric examination of the intratumor infiltration of CD4 + and CD8 + T cells. d,e) The primary and distal tumor growth curves of 4T1 tumor-bearing mice. f) Quantification of pulmonary metastasis nodules in different groups of 4T1 tumor-bearing mice. g) The tumor growth curves of B16F10-bearing mice model (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission. [52] Copyright 2019, Nature Research.

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Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy

Cited by 235 publications

References 96 publications

Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects

Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

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