Au/Si Bilayer Nanodisks with Tunable Localized Surface Plasmon Resonance for Optical Coherence Tomography in the Second Near‐Infrared Window

Abstract

Bioimaging in the second near‐infrared (NIR‐II) window can help to obtain high‐resolution images and a high penetration depth. This study proposes an Au/Si bilayer plasmonic nanodisk (Au/Si ND) that has a resonance wavelength in the NIR‐II window caused by Si ND stacking on top of the Au ND with a resonance wavelength in the first near‐infrared window; the Si ND has a high refractive index. Au/Si NDs are physically synthesized using nanoimprint lithography and vacuum deposition. Optical coherence tomography (OCT) imaging is performed using synthesized Au/Si NDs as OCT contrast agents in the NIR‐II window. Due to the 2D circular shape and its remarkable response to random incident light, the Au/Si NDs exhibit approximately 250‐fold greater OCT signal intensity than do commercial 1D Au nanorods, as well as fourfold greater penetration depth and improved OCT image contrast.

Analysis of characteristics and photoacoustic imaging performance of exogenous contrast agents

“…The simulation employed the properties of Au, Ti, and Pt from the software. The synthesis for the nanodiscs through lithography and vacuum deposition refers to prior publications [11][12][13][14]. We employed developed photoacoustic tomography system to perform photoacoustic analysis [15,16].…”