Atypical melanosis of the foot. A report of three cases in Japanese populations

Nogita, T.

doi:10.1001/archderm.130.8.1042

Cited by 17 publications

(19 citation statements)

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“…Despite their atypical clinical features, such as a large size and a variegated color and/or irregular shape, most of these lesions showed minimal histopathological changes that did not provide evidence of malignancy. These lesions were essentially the same as those reported previously by Nogita et al 9 They distinguished these lesions from acral melanoma in situ by the lack of histopathological evidence of malignancy and designated them as "atypical melanosis of the foot" with undetermined biological behavior. However, we identified amplification of CCND1, a genetic hallmark of acral melanoma, 11 in proliferating melanocytes in a subset of such lesions, which strongly suggests that such atypical pigmented lesions on acral volar skin represent a very early phase of acral melanoma preceding histopathogically recognizable melanoma in situ.…”

Section: Commentsupporting

confidence: 82%

Specific Dermoscopy Patterns and Amplifications of the Cyclin D1 Gene to Define Histopathologically Unrecognizable Early Lesions of Acral Melanoma In Situ

Yamaura

Takata²,

Miyazaki³

et al. 2005

Arch Dermatol

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Section: Commentsupporting

confidence: 82%

Specific Dermoscopy Patterns and Amplifications of the Cyclin D1 Gene to Define Histopathologically Unrecognizable Early Lesions of Acral Melanoma In Situ

Yamaura

Takata²,

Miyazaki³

et al. 2005

Arch Dermatol

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“…3,18 On the other hand, acral-lentiginous and superficial spreading melanomas are usually broad lesions with heterogeneous, variegated pigmentation, and markedly irregular, notched borders. 2,5,12,[15][16][17] Histologically, melanomas exhibit a diffuse proliferation of large, dendritic melanocytes arranged mostly in single cells along the dermoepidermal interface, usually with significant pagetoid upward migration. The dermis usually contains fibrosis, lymphocytic infiltration, and pigmented macrophages.…”

mentioning

confidence: 99%

A Subgroup of Melanocytic Nevi on the Distal Lower Extremity (Ankle) Shares Features of Acral Nevi, Dysplastic Nevi, and Melanoma In Situ

Khalifeh

Taraif

Reed

et al. 2007

American Journal of Surgical Pathology

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Melanocytic lesions in certain locations (eg, genital, breast, acral) may have histologic and clinical features simulating melanoma. Here we describe a group of lesions from the lower distal extremity and analyze their histologic features and possible relation to dysplastic nevi (DN) and melanomas. One hundred fifteen melanocytic lesions from the ankle were retrieved from January 1990 to August 2006 from the files of M. D. Anderson Cancer Center and were classified as benign melanocytic nevi (BN; n=17), DN (n=35), melanomas (MM; n=52), and melanocytic nevi of the ankle with atypical features (MNAAF; ie, cases that did not readily fit in any of the previous categories, n=11). Data analyzed included clinical (age and sex) and histologic features (circumscription, symmetry, cohesiveness of nests, suprabasal melanocytes, confluence, single-cell proliferation, nuclear chromasia, size, and nucleolar features). Follow-up was collected for all MNAAF. MNAAF differ from the other types of lesions in regard to sex incidence (73% in women). The median age of those patients MNAAF was 47 years (range 29 to 76 y). All MNAAF showed moderate-severe architectural disorder whereas 78% showed only mild-moderate cytologic atypia. No MNAAF cases had recurred after follow-up (4 mo to 13 y). This study highlights a group of melanocytic lesions located on the ankle that share histologic features with acral nevi, DN, and melanoma. These lesions are more predominant in females and have moderate to severe architectural atypia but only mild-moderate cytologic atypia. After complete excision, follow-up data indicate an apparently benign outcome. Pathologists should be aware of this type of lesions to avoid overdiagnosis of melanoma.

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“…Among them, atypical melanosis of the foot (AMOF) has interesting features that support this issue. AMOF was first described by Nogita et al in 19947. The authors defined AMOF as a lesion that is clinically suspicious for acral lentiginous melanoma in situ, but with subtle histopathologic findings and a lengthy duration.…”

Section: Discussionmentioning

confidence: 99%

Acral Lentiginous Melanoma Developing during Long-standing Atypical Melanosis: Usefulness of Dermoscopy for Detection of Early Acral Melanoma

Bae

et al. 2011

Ann Dermatol

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Clinical guidelines suggest that suspicious pigmented lesions of the plantar or palmar area require biopsy for early detection of acral melanoma. We present here a case of acral lentiginous melanoma in which various melanocytic atypia was observed at each biopsy site, including focal melanocytic proliferation. We suggest that this atypical melanosis is part of a contiguous phase of invasive tumor growth, which is known as the very early stage of melanoma in situ. In addition, noninvasive dermoscopy has been effective for the early discovery of hidden lesions of acral melanoma.

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Atypical melanosis of the foot. A report of three cases in Japanese populations

Cited by 17 publications

References 0 publications

Specific Dermoscopy Patterns and Amplifications of the Cyclin D1 Gene to Define Histopathologically Unrecognizable Early Lesions of Acral Melanoma In Situ

Specific Dermoscopy Patterns and Amplifications of the Cyclin D1 Gene to Define Histopathologically Unrecognizable Early Lesions of Acral Melanoma In Situ

A Subgroup of Melanocytic Nevi on the Distal Lower Extremity (Ankle) Shares Features of Acral Nevi, Dysplastic Nevi, and Melanoma In Situ

Acral Lentiginous Melanoma Developing during Long-standing Atypical Melanosis: Usefulness of Dermoscopy for Detection of Early Acral Melanoma

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