Atypical lipoma of the tongue

Moore, P. L.; Goede, A. C.; Phillips, David; Carr, Richard

doi:10.1258/0022215011909198

Cited by 20 publications

(14 citation statements)

References 6 publications

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“…Since the comprehensive review of LS of the tongue from 2005 [2], analyzing a total of 32 cases included in two large series [4,5] and in several case reports [6][7][8][9][10][11][12][13][14][15][16][17][18], only one paper reporting two additional cases has been published [3]. Thus, together with our cases, there are only 40 cases of LS of the tongue reported so far.…”

Section: Discussionmentioning

confidence: 94%

Atypical lipomatous tumors of the tongue: report of six cases

et al. 2009

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The occurrence of liposarcoma in the tongue is rare with only 34 cases published so far. We report six new cases of atypical lipomatous tumor (ALT) of the tongue, and detection of mdm-2 and CDK4 expression by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, was performed. The series comprised three males and three females, aged 11-78 years. The tumors arose at the lateral side of the tongue, and in one case, multiple tumor nodules were noted. Follow-up information in five cases (range from 4 to 159 months) revealed one local recurrence at 6 months. Microscopically, four cases had features of lipoma-like ALT, whereas two cases displayed patterns of sclerosing ALT. Immunohistochemically, tumor cells revealed expression of vimentin (five of five), S100 (five of five), mdm-2 (three of five), and CDK4 (four of five). Two cases were also examined by FISH; amplification of mdm-2 gene was found in both cases, whereas amplification of CDK4 gene was present in one case only. To the best of our knowledge, this is the third largest series reporting occurrence of ALT in the tongue and the first one where analysis of mdm-2 and CDK4 proteins/genes expression/amplification was performed. Both these markers may be of help in the differential diagnosis of ALT versus lipoma. Although most ALTs of the tongue behave in the nonaggressive fashion, they may recur locally. Based on current data, the term ALT is strongly recommended for tumors occurring in the tongue to prevent inadequate treatment.

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Section: Discussionmentioning

confidence: 94%

Atypical lipomatous tumors of the tongue: report of six cases

et al. 2009

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“…Liposarcoma in sites of easily accessible areas such as tongue should be classified as atypical lipomas whilst similar tumors arising in inaccessible sites where complete excision of the lesion is difficult to perform should be designated as liposarcoma. [26]…”

Section: Discussionmentioning

confidence: 99%

“…[23679–12142326] The prognosis is usually good with rare recurrence,[1018] especially in case of infiltrating lipomas that tend to invade surrounding muscles. [19] The SCL is not usually encapsulated.…”

Section: Discussionmentioning

confidence: 99%

Spindle cell lipoma of the tongue: A case report of unusual occurrence

Júnior¹,

Aguiar²,

Sartori³

et al. 2013

J Oral Maxillofac Pathol

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Spindle cell lipoma (SCL) is a benign lipomatous tumor predominantly occurring at the posterior neck and shoulder area. Face, forehead, scalp, cheek, perioral area, and upper arm are less common sites. In oral cavity, it is a relatively uncommon neoplasm, particularly in tongue, which is relatively devoid of fat cells. We present a case report of SCL located on the left lateral border of the tongue in a 64-year-old Caucasian female patient with diabetes mellitus type 2 and arterial hypertension.

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“…Secondary changes in form of infarction, hemorrhage and calcification may be seen. 9 Intramuscular lipoma has no capsule and infiltrates into skeletal muscle. 7 It is difficult to distinguish it from a liposarcoma.…”

Section: Discussionmentioning

confidence: 99%

How Important is Histopathology in Management of Benign Lesions of Tongue.

Verma¹,

Azad²,

Verma³

2019

IJCMR

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Introduction: Lipomas are amongst the commonest tumors of human body. Approximately 15 to 20% occur in head and neck but oral cavity is an unusual site. They represent 0.1-5% of all benign intraoral tumors, with most lesions occurring in the buccal mucosa. We report a rare case of intramuscular lipoma of lateral border of tongue. Case report: A 55-year-old female presented with progressive swelling on lateral border of tongue. Complete excision along with healthy margins was done, and histopathology suggested it to be an infiltrating lipoma. Patient had no recurrence in 2 year follow up. Discussion and conclusion: This type of lipoma is rare (<25cases have been reported so far) and only two cases with histopathological documentation could be traced in literature. It has close resemblance to liposarcoma, a malignant tumor with high propensity to recur. Therefore, complete excision with healthy margin is mandatory for this rare clinical entity.

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Atypical lipoma of the tongue

Cited by 20 publications

References 6 publications

Atypical lipomatous tumors of the tongue: report of six cases

Atypical lipomatous tumors of the tongue: report of six cases

Spindle cell lipoma of the tongue: A case report of unusual occurrence

How Important is Histopathology in Management of Benign Lesions of Tongue.

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