Atypical generalized granuloma annulare associated with two visceral cancers

Shimizu, Satoko; Yasui, Chikako; Tsuchiya, Kiyoshi

doi:10.1016/j.jaad.2005.10.045

Cited by 26 publications

(23 citation statements)

References 7 publications

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“…The coexistent neoplasms included carcinomas, lymphomas, and acute myeloid leukemia, while separate manuscripts described additional cases of GA in patients with schwannoma, [12] visceral malignancy, [13] Hodgkin disease, [14] and chronic myelomonocytic leukemia. [15] While Li et al [11] found no definite relationship between GA and malignancy, they suggest the investigation of underlying malignancies particularly for older patients with skin lesions that histologically, but not necessarily clinically, resemble GA.…”

Section: Is Granuloma Annulare Associated With Hematopoietic and Solimentioning

confidence: 99%

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Hawryluk

Izikson

English

2010

American Journal of Clinical Dermatology

109

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Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient's overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.

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Section: Is Granuloma Annulare Associated With Hematopoietic and Solimentioning

confidence: 99%

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Hawryluk

Izikson

English

2010

American Journal of Clinical Dermatology

109

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“…[6][7][8] Granuloma annulare has been reported to exist in the setting of systemic diseases such as diabetes mellitus, malignancy, autoimmune diseases, and infections. [9][10][11][12][13] In one publication, 16 patients with GA had concomitant neoplasms. Although nine of the 16 had lymphoma, only one individual had leukemia (myelodysplastic syndrome/acute myelogenous leukemia).…”

Section: Discussionmentioning

confidence: 99%

Generalized Granuloma Annulare As an Initial Manifestation of Chronic Myelomonocytic Leukemia: A Report of 2 Cases

Hinckley¹,

Walsh²,

Molnár³

et al. 2008

The American Journal of Dermatopathology

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Granuloma annulare is a dermatologic condition of unknown etiology that has been associated with systemic diseases and reported to be a paraneoplastic manifestation. Two patients with generalized granuloma annulare as an initial manifestation of chronic myelomonocytic leukemia are herein described. We suggest that chronic myelomonocytic leukemia should be added to the list of systemic diseases associated with generalized granuloma annulare.

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“…Dermatolojik muayenesinde kollar, bacaklar ve gövde üst kısımlarında dağınık yerleşimli, abdominal, inguinal, lomber ve sakral alanlarda ise yer yer birleşme eğilimi gösteren, bazıları anuler tarzda eritemli papüler lezyonlar ve yer yer postinflamatuvar hiperpigmentasyon alanları belirlenmiştir (Resim 1). Olgumuzun hemogram, rutin biyokimya, tam idrar, tiroid fonksiyon testleri, gaitada gizli kan, anti-HBs, anti-HCV, anti-HIV ve VDRL testi gibi laboratuvar incelemelerinden hemoglobin: 11,2 g/dl (12-16 g/ dl), eritrosit sedimentasyon hızı: 80 mm/sa (0-15 mm/sa), serum total proteini: 9,4 g/dl (5,6 g/dl), aspartat aminotransferaz: 54 U/L (5-34 U/L) ve gama glutamil transferaz: 91 U/L (9-36 U/L) olarak saptanmıştır. Açlık kan şekeri normal olan olgunun oral glukoz tolerans testine yanıtı 0. dk: 97 mg/dl (80-115 mg/dl) ve 2. saat 125 mg/dl (<140 mg/dl) olmak üzere normal sınırlarda belirlenmiştir.…”

Section: Olguunclassified

“…Literatürdeki olguların çoğunda malignite tanısı GA lezyonları çıkmadan önce konulmuş olup, nadiren önceden var olan tanı almamış malignite ya da metastaz ile eş zamanlı olarak GA lezyonlarının oluşabildiği ve malignitenin tedavisinden sonra lezyonlarda da gerileme izlenebildiği bildirilmiştir 4 . Genellikle her iki tablo arasındaki zaman aralığı malignitenin erken evrelerde asemptomatik olması ve gözden kaçması nedeni ile kesin olarak değerlendirilemese de, malignite tanısının GA lezyonlarından 18 ay öncesi ile yedi yıl sonrasına kadar değişen bir süre içinde konulabileceğinden bahsedilmiştir 5,10 . Lösemi veya lenfoması olan çocuk olgularda da GA geliştiği bildirilmiş olmasına rağmen, GA'li olgularda malignite birlikteliğindeki bu artışın yaşlı populasyondaki artmış malignite sıklığına bağlı olabileceği de ileri sürülmüştür.…”

Section: Resim1unclassified