Atypical fungal granuloma of the sphenoid wing

Banuprakash, S; Jolappara, M.; Kesavadas, Chandrasekharan; Saini, Jitender; Rao, Ravi Mohan; Radhakrishnan, V. V.

doi:10.1016/j.neurad.2009.06.003

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…We could find only two similar case reports in literature. Banuprakash et al 10 in 2009 described a mass lesion in the right sphenoid wing with conventional imaging findings that were typical of meningioma. Periodic acid Schiff staining revealed segmented hyphae.…”

Section: Resultsmentioning

confidence: 99%

Spectrum of Magnetic Resonance Imaging Findings in Fungal Infections of Brain

Gupta¹,

Banerjee²,

Saggar³

2018

IJCMSR

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Section: Resultsmentioning

confidence: 99%

Spectrum of Magnetic Resonance Imaging Findings in Fungal Infections of Brain

Gupta¹,

Banerjee²,

Saggar³

2018

IJCMSR

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“…The clinical relevance of these observations is consistent with other recent European studies and clinical case reports, which have documented the presence of fungi in granulomatous structures [18]–[21]. It is clear from these studies that the clinical prognosis is often compromised when patients develop fungal granulomas, such as Candida spp., Cryptococcus spp ., and Aspergillus spp., leading us to suggest that granulomas could be a source of fungal persistence and antifungal resistance [18]–[20], [56]–[59].…”

Section: Discussionmentioning

confidence: 99%

First Human Model of In Vitro Candida albicans Persistence within Granuloma for the Reliable Study of Host-Fungi Interactions

et al. 2012

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BackgoundThe balance between human innate immune system and Candida albicans virulence signaling mechanisms ultimately dictates the outcome of fungal invasiveness and its pathology. To better understand the pathophysiology and to identify fungal virulence-associated factors in the context of persistence in humans, complex models are indispensable. Although fungal virulence factors have been extensively studied in vitro and in vivo using different immune cell subsets and cell lines, it is unclear how C. albicans survives inside complex tissue granulomas.Methodology/Principal FindingWe developed an original model of in vitro human granuloma, reproducing the natural granulomatous response to C. albicans. Persistent granulomas were obtained when the ratio of phagocytes to fungi was high. This in vitro fungal granuloma mimics natural granulomas, with infected macrophages surrounded by helper and cytotoxic T lymphocytes. A small proportion of granulomas exhibited C. albicans hyphae. Histological and time-lapse analysis showed that C. albicans blastoconidia were located within the granulomas before hyphae formation. Using staining techniques, fungal load calculations, as well as confocal and scanning electron microscopy, we describe the kinetics of fungal granuloma formation. We provide the first direct evidence that C. albicans are not eliminated by immunocompetent cells inside in vitro human granulomas. In fact, after an initial candicidal period, the remaining yeast proliferate and persist under very complex immune responses.Conclusions/SignificanceUsing an original in vitro model of human fungal granuloma, we herein present the evidence that C. albicans persist and grow into immunocompetent granulomatous structures. These results will guide us towards a better understanding of fungal invasiveness and, henceforth, will also help in the development of better strategies for its control in human physiological conditions.

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