Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations

Cheuk, Wah; Lo, Elena Siu Fong; Chan, Amanda; Chan, John K.

doi:10.1053/hupa.2002.125370

Cited by 44 publications

(23 citation statements)

References 12 publications

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“…Tubular epithelia in patients with long-term dialysis often show papillary hyperplasia, and these lesions are called atypical cysts when atypia is associated. 10,11 Subsequent hyperplasia may be morphologically adequate to postatrophic hyperplasia of the prostate. 12 The third factor is mitochondrial DNA alteration.…”

Section: Discussionmentioning

confidence: 98%

“…14 Additionally, Cheuk et al have described that some possible precursor lesions of ACDassociated RCC, including papillary tuft, cribriform lesion, or atypical cysts, show a gain of chromosomes 7 and 17. 11 These changes may easily result in oncogenesis in renal tubular epithelial cells. Eventually, these several factors may contribute to the formation of the complex histological features of ACD-associated RCC.…”

Section: Discussionmentioning

confidence: 99%

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Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study

et al. 2011

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Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently identified. However, there are only a few genetic studies to date. In this article, we performed an immunohistochemical and fluorescence in situ hybridization (FISH) study for six cases including one case with sarcomatoid change. As a result, we observed frequent immunohistochemical expression of AMACR. FISH of chromosome 3 showed trisomy for three cases, monosomy for two cases, and disomy for one case. Additionally, FISH of chromosome 16 showed trisomy for three cases, monosomy for two cases, and both trisomy and monosomy for one case. Furthermore, both the carcinomatous area and the sarcomatoid area of one ACD-associated RCC with sarcomatoid change revealed monosomy of chromosomes 3, 9, and 16 but showed disomy of chromosome 14. In conclusion, the numerical abnormalities of chromosomes 3 and 16, irrespective of gain or loss, may be characteristic of ACD-associated RCC.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study

et al. 2011

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“…In certain scenarios, though, the development of cysts is associated with the development of renal cell carcinoma (RCC), such as in patients with acquired cystic disease of the kidney or with von Hippel-Lindau disease. [189][190][191] While it is generally accepted that not all cysts progress to cancer and that not all cancers originate as cysts, several studies have shown a link between atypical renal cysts and malignancy. However, a diagnosis of an atypical renal cyst is essentially impossible without complete resection, and as such the natural history of these lesions remains uncertain.…”

Section: Atypical Renal Cystsmentioning

confidence: 99%

“…Clear cell papillary RCC and translocation-associated RCC may also show extensive cystic change, as well as some benign lesions, such as cystic nephroma and angiomyolipoma with epithelial cysts. 193 Several studies 190,192,194 have demonstrated that the epithelial cells lining some renal cysts harbor cytogenetic alterations similar to those seen in RCC, such as 3p deletion in clear cell RCC and trisomy of 7 and/or 17 in papillary RCC. Such findings support the notion that at least some cysts are precancerous.…”

Section: Atypical Renal Cystsmentioning

confidence: 99%

Precursor Lesions of Urologic Malignancies

Khani¹,

Robinson²

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Precursor lesions of urologic malignancies are established histopathologic entities, which are important not only to recognize for clinical purposes, but also to further investigate at the molecular level in order to gain a better understanding of the pathogenesis of these malignancies. Objective.— To provide a brief overview of precursor lesions to the most common malignancies that develop within the genitourinary tract with a focus on their clinical implications, histologic features, and molecular characteristics. Data Sources.— Literature review from PubMed, urologic pathology textbooks, and the 4th edition of the World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs. All photomicrographs were taken from cases seen at Weill Cornell Medicine or from the authors' personal slide collections. Conclusions.— The clinical importance and histologic criteria are well established for the known precursor lesions of the most common malignancies throughout the genitourinary tract, but further investigation is warranted at the molecular level to better understand the pathogenesis of these lesions. Such investigation may lead to better risk stratification of patients and potentially novel treatments.

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“…RCC associated with ACDK is commonly considered to be derived from the proximal tubules as well as concomitant cysts arising from the proximal tubules as a result of epithelial hyperplasia, which frequently includes proliferating atypical cells. 7 Compared to sporadic RCC in non-dialysis patients, the high frequency (42-71%) of papillary RCC in dialysis patients has been reported. 8 However, Tickoo et al suggested new histological subtypes of renal neoplasia in patients with end-stage renal disease, which was called acquired cystic disease-associated RCC and clear-cell papillary RCC of the end-stage kidneys.…”

Section: Discussionmentioning

confidence: 99%

Collecting duct carcinoma with acquired cystic disease of the kidney in a long‐term hemodialysis patient

et al. 2008

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Abstract:We report a very rare case of collecting or Bellini duct carcinoma (CDC) found in a 60-year-old male who had received hemodialysis therapy for 21 years. Screening with ultrasonography revealed a solid tumor originating from the cyst wall in the right kidney with acquired cystic disease of the kidney. Subsequent computed tomography (CT) and angiography could not detect another renal tumor. Right radical nephrectomy was performed. The tumor detected preoperatively was composed of papillary renal cell tumor (RCC) and multiple clear cell carcinoma, pathologically. In addition to the tumors, CDC was revealed in the central medulla with the involvement of regional lymph nodes. Three months later, left nephrectomy was performed because left RCC was suspected during CT. The histological diagnosis was multiple clear cell carcinomas. Peritonitis carcinomatosa appeared and the patient died 13 months later.

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Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations

Cited by 44 publications

References 12 publications

Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study

Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study

Precursor Lesions of Urologic Malignancies

Collecting duct carcinoma with acquired cystic disease of the kidney in a long‐term hemodialysis patient

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