Atypical Antipsychotic Use Among Long-Term Care Residents with Parkinson's Disease and Comorbid Depression

Chekani, Farid; Johnson, M.L.; Chen, H; Sherer, JT; Holmes, HM; Aparasu, Rajender R.

doi:10.1016/j.jval.2018.04.1388

Cited by 2 publications

(2 citation statements)

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“…In a study conducted according to the 2015 Beers criteria, Cox regression analyses revealed an increased risk of pneumonia in nursing home residents with PD who were taking inappropriate antipsychotic agents compared with those taking appropriate agents [13]. Older people with PD in long-term care who have therapy-related psychosis and use inappropriate antipsychotic medications may experience a deterioration in parkinsonian symptoms [37]. Inappropriate antipsychotic medications can potentially affect overall voluntary movements and swallowing movements because of their antagonism of the D 2 receptors in patients with PD [38,39].…”

Section: Discussionmentioning

confidence: 99%

Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study

Huang¹,

Kuo²,

Kuan³

et al. 2021

Int. J. Med. Sci.

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Objective: To investigate the risk of pneumonia associated with the use of antipsychotic drugs in older-adult patients with Parkinson's disease (PD) in Taiwan. Methods: This case-control study was based on data from the longitudinal health insurance database in Taiwan. We analyzed the data of 51,158 older patients with PD for the period between 2001 and 2016. To reduce the potential confounding caused by unbalanced covariates in nonexperimental settings, we used propensity score matching to include older patients without pneumonia to serve as the control group. Results: Compared with patients who had never taken antipsychotics, current (adjusted odds ratios [aOR] =1.63, 95% confidence interval [CI] = 1.51-1.75), recent (aOR = 1.63, 95% CI = 1.52-1.74), and past (aOR = 1.89, 95% CI = 1.80-2.00) users of antipsychotics had a higher risk of incident pneumonia. Among typical and atypical antipsychotics, haloperidol and clozapine were associated with higher risks of incident pneumonia, respectively. By contrast, aripiprazole was not associated with a higher risk of pneumonia. Conclusion: Older patients with PD receiving typical antipsychotics or atypical antipsychotics had a higher risk of pneumonia. Among these antipsychotics, clozapine had the highest risk of pneumonia. Clinicians should pay attention to the risk of pneumonia in older patients with PD who receive typical antipsychotics and atypical antipsychotics.

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Section: Discussionmentioning

confidence: 99%

Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study

Huang¹,

Kuo²,

Kuan³

et al. 2021

Int. J. Med. Sci.

View full text Add to dashboard Cite

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“…Because these processes are imperfect and incomplete, collected data must be extended by manual data acquisition and re-checked for quality control. 26 Some systems have been developed to enable such a data transfer, but describe only early experiences 27 or were developed specifically for the widely used systems i2b2 as CDW and REDCap as EDC. 28 - 30 They partially allow for customized aggregations of multiple CDW variables, but were primarily designed to map single CDW variables to single EDC variables.…”

Section: Introductionmentioning

confidence: 99%

Automated provision of clinical routine data for a complex clinical follow-up study: A data warehouse solution

Kaspar

Fette

Hanke

et al. 2022

Health Informatics J

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A deep integration of routine care and research remains challenging in many respects. We aimed to show the feasibility of an automated transformation and transfer process feeding deeply structured data with a high level of granularity collected for a clinical prospective cohort study from our hospital information system to the study’s electronic data capture system, while accounting for study-specific data and visits. We developed a system integrating all necessary software and organizational processes then used in the study. The process and key system components are described together with descriptive statistics to show its feasibility in general and to identify individual challenges in particular. Data of 2051 patients enrolled between 2014 and 2020 was transferred. We were able to automate the transfer of approximately 11 million individual data values, representing 95% of all entered study data. These were recorded in n = 314 variables (28% of all variables), with some variables being used multiple times for follow-up visits. Our validation approach allowed for constant good data quality over the course of the study. In conclusion, the automated transfer of multi-dimensional routine medical data from HIS to study databases using specific study data and visit structures is complex, yet viable.

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Atypical Antipsychotic Use Among Long-Term Care Residents with Parkinson's Disease and Comorbid Depression

Cited by 2 publications

References 0 publications

Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study

Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study

Automated provision of clinical routine data for a complex clinical follow-up study: A data warehouse solution

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