Atypical and Typical Bacteria in Children with Community Acquired Pneumonia

Jama-Kmiecik, Agnieszka; Frej−Mądrzak, Magdalena; Sarowska, Jolanta; Teryks−Wołyniec, Dorota; Skiba, A; Choroszy−Król, Irena

doi:10.1007/5584_2019_377

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The primary pathogens causing CAP among children encompass a diverse range of typical bacteria, atypical bacteria, and viruses, as supported by previous studies 15 – 17 . Understanding the aetiology of CAP is crucial for effective diagnosis, treatment, and prevention strategies.…”

Section: Discussionsupporting

confidence: 69%

Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia

Tran,

Hoang,

Goumballa

et al. 2024

Sci Rep

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To investigate potential respiratory pathogens in children with community-acquired pneumonia (CAP) and risk factors for severe disease. This prospective study was conducted among 467 children at the Thai Binh Paediatric Hospital, Vietnam between 1 July 2020 and 30 June 2021. Clinical data and laboratory results were collected. Twenty-four respiratory microorganisms were tested from nasopharyngeal swabs using real-time PCR. Logistical regression was used to estimate a factor’s adjusted odd ratios of the severity of disease. Mean age of patients = 15.4 ± 13.3 months, 63.0% were male. Over 97% of patients had a positive PCR result. 87% of patients were positive for multiple (up to eight) microorganisms. Rhinovirus (46%), respiratory syncytial virus (RSV) (24%), enterovirus (17%), and parainfluenza viruses-3 (13%) were the most frequent viruses. H. influenzae (61%), S. pneumoniae (45%) and M. catarrhalis (30%) were the most common bacteria. 128 (27%) cases were classified as severe pneumonia. Presence of smokers at home (aOR 2.11, 95% CI 1.27–3.52, P value = 0.004), CRP level ≥ 50 mg/dL (aOR 6.11, 95% CI 3.86–9.68, P value < 0.0001), RSV (aOR 1.78, 95% CI 1.07–2.96, P value = 0.03) and H. influenzae (aOR 1.66, 95% CI 1.03–2.67, P value = 0.04) PCR detection associated with a higher risk of severe pneumonia; ,. Causative agents of pneumonia in children are complex. Children positive with RSV and H. influenzae need to be closely monitored to prevent severe pneumonia.

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Section: Discussionsupporting

confidence: 69%

Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia

Tran,

Hoang,

Goumballa

et al. 2024

Sci Rep

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“…Результаты. Продолжительность пребывания на стационарном лечении составила (13,3±0,62) [5,8,11]. Використання в дослідженнях сучасних і більш чутливих методів діагностики (полімеразноланцюгова реакція, серологічні тести) збільшує кількість розшифрованих випадків і розширює кількість виявлених збудників.…”

Section: буковинский медицинский вестник 2021 т25 № 3 (99) с 77-82unclassified

Pharmaco-economic features of hospital treatment of acute community-acquired pneumonia in children

Nechytailo¹,

Popelyuk²,

Dolzhenko³

2021

Buk. Med. Herald

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The goal. Тo analyze the features of treatment and medical expenses in children hospitalized for acute community-acquired pneumonia. Materials and methods. The study analyzed medical records and examined 51 children aged 2 to 17 months hospitalized for pneumonia. In patients studied clinical symptoms, severity, structure and duration of basic treatment measures, their cost. Results. The duration of inpatient treatment was 13.3±0.62 days with subsequent outpatient treatment and rehabilitation. Antibiotics, antipyretics, antihistamines, mucolytics and corticosteroid hormones were used in the treatment. The total cost of treatment for one case averaged 2346.9±145.7 hryvnias. The most expensive were the costs of antibiotics, and the cheapest - the antipyretics. Given the community-acquired nature of the process, the initial use of third- and fourth-generation cephalosporins was irrational and significantly increased the cost of treatment. Conclusions. The introduction of a new model of medicine focuses on the optimization of treatment tactics and the rational choice of antibiotics for acute community-acquired pneumonia. In antibacterial therapy is still inadequate, from a clinical and economic point of view, the choice of drugs. In the treatment of this disease, the role of pathogenetic therapy to restore the processes of mucociliary clearance and prevention of dysbiosis on the background of the use of antibiotics has increased.

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Chlamydophila pneumoniae-associated community-acquired pneumonia in paediatric patients of a tertiary care hospital in Mexico: molecular diagnostic and clinical insights

Merida Vieyra,

De Colsa Ranero,

Palacios Reyes

et al. 2023

Sci Rep

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Chlamydophila pneumoniae is a cause of community-acquired pneumonia (CAP) and responsible for 1–2% of cases in paediatric patients. In Mexico, information on this microorganism is limited. The aim of this study was to detect C. pneumoniae using two genomic targets in a real-time PCR and IgM/IgG serology assays in paediatric patients with CAP at a tertiary care hospital in Mexico City and to describe their clinical characteristics, radiological features, and outcomes. A total of 154 hospitalized patients with diagnosis of CAP were included. Detection of C. pneumoniae was performed by real-time PCR of the pst and arg genes. Complete blood cell count, C-reactive protein measurement and IgM and IgG detection were performed. Clinical-epidemiological and radiological data from the patients were collected. C. pneumoniae was detected in 25 patients (16%), of whom 88% had underlying disease (P = 0.014). Forty-eight percent of the cases occurred in spring, 36% in girls, and 40% in children older than 6 years. All patients had cough, and 88% had fever. Interstitial pattern on chest-X-ray was the most frequent (68%), consolidation was observed in 32% (P = 0.002). IgM was positive in 7% and IgG in 28.6%. Thirty-six percent presented complications. Four percent died. A high proportion showed co-infection with Mycoplasma pneumoniae (64%). This is the first clinical report of C. pneumoniae as a cause of CAP in Mexican paediatric patients, using two genomic target strategy and serology. We found a frequency of 16.2% with predominance in children under 6 years of age. In addition; cough and fever were the most common symptoms. Early detection of this pathogen allows timely initiation of specific antimicrobial therapy to reduce development of complications. This study is one of the few to describe the presence of C. pneumoniae in patients with underlying diseases.

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Atypical and Typical Bacteria in Children with Community Acquired Pneumonia

Cited by 5 publications

References 26 publications

Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia

Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia

Pharmaco-economic features of hospital treatment of acute community-acquired pneumonia in children

Chlamydophila pneumoniae-associated community-acquired pneumonia in paediatric patients of a tertiary care hospital in Mexico: molecular diagnostic and clinical insights

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