Atypical Acquired Pediatric Horner Syndrome

Early Diagnosis of Horner Syndrome Using Topical Apraclonidine

“…It is apparent that the development of sympathetic supersensitivity sufficient to elicit a response to apraclonidine testing is present relatively soon after the development of HS. The absence of observable ptosis in HS, as in our case, has been described (22) and is also consistent with incomplete interruption of sympathetic innervations. It has been suggested that these partial responses, including our case, may represent incomplete lesions of the sympathetic supply sufficient to produce sympathetic supersensitivity and pupillary dilation but not reversal of anisocoria (7).…”

Early Diagnosis of Horner Syndrome Using Topical Apraclonidine

“…It is apparent that the development of sympathetic supersensitivity sufficient to elicit a response to apraclonidine testing is present relatively soon after the development of HS. The absence of observable ptosis in HS, as in our case, has been described (22) and is also consistent with incomplete interruption of sympathetic innervations. It has been suggested that these partial responses, including our case, may represent incomplete lesions of the sympathetic supply sufficient to produce sympathetic supersensitivity and pupillary dilation but not reversal of anisocoria (7).…”

Unilateral Straight Hair—A Symptom of Acquired Horner's Syndrome in a Neonate

“…Other authors did not mention at what time point the change of hair structure appeared. 2 3 8 We do not believe that this phenomenon was due to spontaneous change of hair texture during growth of the child because this would take longer than just a few months. 10 …”

Horner syndrome in a pediatric patient

“…5,9 A lesser-known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis. 9,10 In these atypical HS cases, which may actually represent as many as 40% of pediatric cases, the risk of having an underlying neuroblastoma is increased fourfold. 4 The treatment of neuroblastoma varies due to the high heterogeneity in location, grade, and stage at diagnosis.…”

“…Delayed diagnosis or misdiagnosed pediatric HS is not uncommon, especially when signs develop sequentially, with anisocoria often reported to precede ptosis. In fact, a large proportion of pediatric HS seem to present with just one sign or symptom and no other suggestive history 5,9 . A lesser‐known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis 9,10 .…”

“…In fact, a large proportion of pediatric HS seem to present with just one sign or symptom and no other suggestive history. 5 , 9 A lesser‐known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis. 9 , 10 In these atypical HS cases, which may actually represent as many as 40% of pediatric cases, the risk of having an underlying neuroblastoma is increased fourfold.…”

Early Diagnosis of Horner Syndrome Using Topical Apraclonidine

“…It is apparent that the development of sympathetic supersensitivity sufficient to elicit a response to apraclonidine testing is present relatively soon after the development of HS. The absence of observable ptosis in HS, as in our case, has been described (22) and is also consistent with incomplete interruption of sympathetic innervations. It has been suggested that these partial responses, including our case, may represent incomplete lesions of the sympathetic supply sufficient to produce sympathetic supersensitivity and pupillary dilation but not reversal of anisocoria (7).…”

Unilateral Straight Hair—A Symptom of Acquired Horner's Syndrome in a Neonate

“…Other authors did not mention at what time point the change of hair structure appeared. 2 3 8 We do not believe that this phenomenon was due to spontaneous change of hair texture during growth of the child because this would take longer than just a few months. 10 …”

Horner syndrome in a pediatric patient

“…5,9 A lesser-known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis. 9,10 In these atypical HS cases, which may actually represent as many as 40% of pediatric cases, the risk of having an underlying neuroblastoma is increased fourfold. 4 The treatment of neuroblastoma varies due to the high heterogeneity in location, grade, and stage at diagnosis.…”

“…Delayed diagnosis or misdiagnosed pediatric HS is not uncommon, especially when signs develop sequentially, with anisocoria often reported to precede ptosis. In fact, a large proportion of pediatric HS seem to present with just one sign or symptom and no other suggestive history 5,9 . A lesser‐known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis 9,10 .…”

“…In fact, a large proportion of pediatric HS seem to present with just one sign or symptom and no other suggestive history. 5 , 9 A lesser‐known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis. 9 , 10 In these atypical HS cases, which may actually represent as many as 40% of pediatric cases, the risk of having an underlying neuroblastoma is increased fourfold.…”

Early Diagnosis of Horner Syndrome Using Topical Apraclonidine

“…It is apparent that the development of sympathetic supersensitivity sufficient to elicit a response to apraclonidine testing is present relatively soon after the development of HS. The absence of observable ptosis in HS, as in our case, has been described (22) and is also consistent with incomplete interruption of sympathetic innervations. It has been suggested that these partial responses, including our case, may represent incomplete lesions of the sympathetic supply sufficient to produce sympathetic supersensitivity and pupillary dilation but not reversal of anisocoria (7).…”

Unilateral Straight Hair—A Symptom of Acquired Horner's Syndrome in a Neonate

“…Other authors did not mention at what time point the change of hair structure appeared. 2 3 8 We do not believe that this phenomenon was due to spontaneous change of hair texture during growth of the child because this would take longer than just a few months. 10 …”

Horner syndrome in a pediatric patient

“…5,9 A lesser-known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis. 9,10 In these atypical HS cases, which may actually represent as many as 40% of pediatric cases, the risk of having an underlying neuroblastoma is increased fourfold. 4 The treatment of neuroblastoma varies due to the high heterogeneity in location, grade, and stage at diagnosis.…”

“…Delayed diagnosis or misdiagnosed pediatric HS is not uncommon, especially when signs develop sequentially, with anisocoria often reported to precede ptosis. In fact, a large proportion of pediatric HS seem to present with just one sign or symptom and no other suggestive history 5,9 . A lesser‐known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis 9,10 .…”

“…In fact, a large proportion of pediatric HS seem to present with just one sign or symptom and no other suggestive history. 5 , 9 A lesser‐known feature of HS leading to delays in diagnosis is the frequently intermittent nature of ptosis or miosis. 9 , 10 In these atypical HS cases, which may actually represent as many as 40% of pediatric cases, the risk of having an underlying neuroblastoma is increased fourfold.…”