Attitude towards physical activity in patients with multiple sclerosis: a cohort study

Frau, Jessica; Coghe, Giancarlo; Lorefice, Lorena; Fenu, Giuseppe; Cadeddu, Barbara; Marrosu, Maria Giovanna; Cocco, Eleonora

doi:10.1007/s10072-015-2100-x

Cited by 23 publications

(20 citation statements)

References 33 publications

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“…29,30 A recent study among 118 patients with MS found that, after diagnosis, 38% of participants stopped physical activity and many reduced frequency of activity. 31 In our study, participants could have possibly reduced physical activity in response to prediagnosis symptoms. 31 In an effort to address this, we carried out several analyses.…”

Section: Resultsmentioning

confidence: 75%

“…31 In our study, participants could have possibly reduced physical activity in response to prediagnosis symptoms. 31 In an effort to address this, we carried out several analyses. Though total physical activity was weakly associated with a lower rate of MS in non-lagged analyses, this trend was no longer present when we carried out 6-year lagged analyses.…”

Section: Resultsmentioning

confidence: 75%

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Physical activity and the incidence of multiple sclerosis

et al. 2016

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Objective: To study whether physical activity during adulthood or early life is associated with multiple sclerosis (MS) incidence in 2 prospective cohorts of women.Methods: Women in the Nurses' Health Study (NHS) (n 5 81,723; 1986-2004) and NHS II (n 5 111,804; 1989-2009) reported recent physical activity at baseline and in selected follow-up questionnaires. Using this information, we calculated total metabolic equivalent hours of physical activity per week, a measure of energy expenditure. There were 341 confirmed MS cases with first symptoms after baseline. Participants also reported early-life activity. To estimate relative rates (RRs) and 95% confidence intervals (CIs), we used Cox proportional hazards models, adjusting for age, latitude of residence at age 15, ethnicity, smoking, supplemental vitamin D, and body mass index at age 18.Results: Compared with women in the lowest baseline physical activity quartile, women in the highest quartile had a 27% reduced rate of MS (RR pooled 5 0.73, 95% CI 0.55-0.98; p-trend 0.08); this trend was not present in 6-year lagged analyses. Change in physical activity analyses suggested that women reduced activity before onset of MS symptoms. In NHS and NHS II, higher strenuous activity at ages 18-22 years was weakly associated with a decreased MS rate. However, in NHS II, total early-life activity at ages 12-22 was not associated with MS.Conclusions: Though higher physical activity at baseline was weakly associated with lower MS risk, this may have been due to women reducing physical activity in response to subclinical MS. Clinical research has found that among patients with multiple sclerosis (MS) with mild or moderate disability, exercise improves muscular strength and aerobic capacity and may improve mobility, fatigue, and health-related quality of life.1 Previous work has suggested exercise or physical activity might even slow progression of MS, though evidence is inconsistent.2 Exercise could potentially modify MS disease activity via multiple mechanisms, including modulating immune factors and stress hormones and mediating expression of neuronal growth factors. 3,4 Little research has assessed the association of physical activity with the risk of incident MS. 5-7Two case-control studies found that, before diagnosis, individuals with MS tended to be more physically active than controls. 5,6 Another found no difference in pre-onset physical activity levels between cases and controls.7 These studies, however, collected physical activity exposure after MS diagnosis and did not use detailed or validated questionnaires to assess physical activity. Given this background, we prospectively examined the association between physical activity during early life and during adulthood with MS incidence in 2 large cohorts of US women: the Nurses' Health Study (NHS) and the NHS II (NHS II).

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 75%

Physical activity and the incidence of multiple sclerosis

et al. 2016

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“…In summary, however, the items did not lie beyond the critical cut-off of .95, and, more importantly, there is a content-related argument for this finding. PwMS are typically well aware of the array of beneficial effects resulting from PA, especially when it is executed in a disease-adapted fashion (Frau et al, 2015). Therefore, we continued the development process with the inclusion of these two factors.…”

Section: Persons With Multiple Sclerosis (Study 1)mentioning

confidence: 99%

Competencies for a healthy physically active lifestyle: Second-order analysis and multidimensional scaling

Carl

Sudeck

Pfeifer

2020

Preprint

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The model of physical activity-related health competence (PAHCO) assumes that individuals require movement competence, control competence, and self-regulation competence to lead a healthy, physically active lifestyle. Although previous research has already established some measurement factors (n = 8) of the three dimensions, no attempts have so far been made to statistically aggregate them on the sub-competence level. Therefore, the goal of the present study was to test two additional factors for PAHCO and subsequently model the second-order structure with two samples from the fields of rehabilitation and prevention. We conducted two questionnaire surveys with persons with multiple sclerosis (n = 475) and teaching students undergoing a basic qualification course in physical education (n = 502). After performing exploratory items analysis, we used second-order confirmatory factor analysis (CFA) and multidimensional scaling to investigate whether the scales could be bundled in accordance with the PAHCO model. The CFAs with ten factors (42 items) demonstrated a good model fit. In contrast, the second-order analysis with a simple loading structure on the three sub-competencies revealed an unacceptable model fit. Instead, a second-order model variant was preferred (CFI = 0.926, RMSEA = 0.048, SRMR = 0.065) in which body awareness and self-efficacy had theory-conform cross-loadings. The results of multidimensional scaling (two-dimensional solution) were in line with the extracted second-order structure. The present results suggested that the extension of the measurement instrument to ten first-order factors was psychometrically justified. The results from the second-order analyses provided the basis for the creation of sum scores, representing manifest indicators of movement competence, control competence, and self-regulation competence. Future studies are needed that relate the sub-competencies of PAHCO to indicators of health-enhancing physical activity in relevant target Groups.

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“…No language or date restrictions were applied. Bibliographic citations of relevant review articles 8,[29][30][31] were also searched to ascertain articles not identified through the database search.…”

Section: Search Strategymentioning

confidence: 99%

Effect of Exercise Interventions on Anxiety in People with Multiple Sclerosis

Gascoyne

Karahalios

Demaneuf

et al. 2019

International Journal of MS Care

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Background: Evidence suggests that exercise can alleviate symptoms associated with multiple sclerosis (MS). However, it is unclear whether exercise alleviates symptoms of anxiety, present in one-third of people with MS. This systematic review and meta-analysis investigates whether exercise interventions are effective in reducing anxiety in people with MS. Methods: CINAHL, Embase, MEDLINE, PsycINFO, and the Cochrane Controlled Clinical Trials Register were searched to identify relevant randomized controlled trials (RCTs) published up to March 30, 2018. The primary outcome was postintervention difference in anxiety scores between intervention and control groups. Using a restricted maximum likelihood random-effects model, standardized mean differences were pooled and heterogeneity was estimated. Risk of bias was assessed using an a priori modified Cochrane Risk of Bias 2.0 tool. Results: Four RCTs with 133 participants were included. Exercise type included walking, aerobic activities, and cycling. Intervention duration ranged from 8 to 26 weeks. The pooled standardized mean difference in anxiety score was −0.16 (95% CI, −0.50 to 0.19), without heterogeneity. Two studies had high risk of bias, and two had some risk of bias. Conclusions: Based on available RCT data, exercise does not seem to have an effect on anxiety in people with MS. These results should be interpreted with caution because studies had concerns of bias and small sample sizes, and anxiety was not the primary outcome measure. Future studies should exhibit sufficient reporting standards, alongside publishing protocols. There is opportunity to investigate the effect of exercise in people with MS experiencing clinically relevant levels of anxiety rather than in the general MS population.

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Attitude towards physical activity in patients with multiple sclerosis: a cohort study

Cited by 23 publications

References 33 publications

Physical activity and the incidence of multiple sclerosis

Physical activity and the incidence of multiple sclerosis

Competencies for a healthy physically active lifestyle: Second-order analysis and multidimensional scaling

Effect of Exercise Interventions on Anxiety in People with Multiple Sclerosis

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