Attenuation of Oxidative Stress by Ischemic Preconditioning in an Experimental Model of Intraabdominal Hypertension

Leventi, Aikaterini; Argyra, Eriphylli; Avraamidou, Alexandra; Marinis, Athanasios; Asonitis, Spyridon; Περρέα, Δέσποινα; Voros, Dionysios; Theodoraki, Kassiani

doi:10.3109/08941939.2015.1031922

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Renal IRI is inevitable during LPN in most cases and is closely related to the decreased renal function after surgery. [4][5][6] This signifies the urgency of more protective and practicable approaches. PP is a novel nonpharmacological strategy to induce IP, which can be easily and securely implemented before LPN through mechanical insufflation and desufflation.…”

Section: Discussionmentioning

confidence: 99%

“…The performed protocol of PP in our recent study will consist of three cycles of 5 min insufflation and 5 min desufflation instead of one cycle of 15 min insufflation and 15 min desufflation as done in previous studies. 6 The prolonged insufflation with 15 min could cause a lethal injury to abdominal organs before LPN, although the total ischaemia and reperfusion duration of the two procedures are both 30 min. To evaluate the short-term effect of PP on renal function, the postoperative level of Cys C is introduced as one of the primary outcomes, for Cys C is more sensitive than traditional SCr or blood urea nitrogen in the early detection of kidney injury.…”

Section: Discussionmentioning

confidence: 99%

“…4 5 Moreover, the increase of intra-abdominal pressure in LPN can decrease the blood flow of abdominal viscera including kidney, and further aggravate the renal IRI. 6 Several strategies have been proposed to reduce renal IRI during LPN. [7][8][9] However, most methods are relatively complicated to implement or merely limited to surgical expertise.…”

Section: Introductionmentioning

confidence: 99%

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Pneumoperitoneum preconditioning for the prevention of renal function after laparoscopic partial nephrectomy: protocol for a double-blind randomised controlled trial

Zhou

et al. 2020

BMJ Open

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IntroductionRenal ischaemia reperfusion injury is an inevitable pathophysiology in different clinical situations including laparoscopic partial nephrectomy (LPN), which can obviously decrease the renal function after surgery. Pneumoperitoneum preconditioning (PP) is a promising approach that can yield a protective effect on kidney, which has already been demonstrated in some animal models. The present study is designed to assess whether the PP can yield a clinical renoprotective role after LPN.Methods and analysisThis study is a randomised, prospective, double-blind and parallel controlled clinical trial. Eligible participants will be patients with renal tumours and willing to choose elective LPN. Patients randomised to the treatment arm will receive PP consisted of three cycles of 5 min insufﬂation and 5 min desufﬂation before LPN, while the control arm will receive a sham operation. The primary endpoints are glomerular filtration rate and the level of serum cystatin C within 6 months after desufﬂation. The secondary endpoints are serum creatinine, estimated glomerular filtration rate, alanine transaminase, serum amylase, intestinal fatty acid binding protein, postoperative hospital stay, the incidence of adverse events and mortality in postoperative 6 months.Ethics and disseminationThis study has been approved by the institutional ethics committee of Nanjing First Hospital. The results of this study will be reported faithfully through scientific conferences or published articles.Trial registration numberNCT03822338.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pneumoperitoneum preconditioning for the prevention of renal function after laparoscopic partial nephrectomy: protocol for a double-blind randomised controlled trial

Zhou

et al. 2020

BMJ Open

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“…Since the preliminary works of Murry et al ischemic preconditioning (IPC) has become a more established entity (11). Leventi and his colleagues (12) from London Whittington Hospital and the Aretaieion University Hospital and the University of Athens in Greece studied whether the phenomenon of IPC attenuated oxidative stress after intra-abdominal hypertension (IAH). It was evident that IPC diminished oxidative stress in pigs with IAH.…”

Section: Ischemic Preconditioning Attenuates Oxidative Stress Of Intrmentioning

confidence: 99%

Advances in Ischemia and Reperfusion

Toledo‐Pereyra¹

2015

Journal of Investigative Surgery

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Many are the references that pertain to ischemia reperfusion (IR) in the literature, especially in the last 20 years where there has been a dedicated commitment of scientists, physicians and surgeons to advance the field of IR (1-3). All organs have been studied in the past and the majority of therapeutic developments as it pertain to cardiovascular, neurological, digestive, renal and other surgical diseases frequently seen in clinical practice (4, 5). Because of the interest of so many dedicated professionals, this issue is oriented to review several recent advances. In particular, those that have made some progress in the treatment or understanding of the IR phenomenon. We have considered any work with the potential to establish a link to other developments in the ischemia and reperfusion field. One editorial and eight scientific works are assembled in this special IR themed issue. These works are ranging from new methods to treat IR injury, characteristics defining IR, consequences of this lesion, new methodologies and new animal models of disease. We are pleased that our issue is international, including works from the United States,

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“…Elevation of intra-abdominal pressure (IAP) affects hemodynamics and can be crucial factor triggering organ injury due to tissue ischemia and oxidative stress [1].…”

Section: Introductionmentioning

confidence: 99%

Effects of Rivastigmine on Behavioral Tests for Passive Training in Rats with Abdominal Hypertension

Dimitrova¹,

Turiiski²,

Ardasheva³

et al. 2016

SAJP

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Intra-abdominal hypertension may increase brain venous pressure, which may lead to brain injury. Elevated intracranial pressure causes encephalopathy and the risk of neuronal damage due to the sharp decrease in cerebral perfusion pressure. Increased intra-abdominal pressure (IIAP) modulates brain perfusion, induces hypoxic changes and impairs memory and other cognitive functions. Rivastigmine, last introduced in clinical practice cholinesterase inhibitor, is a second generation carbamate-based, reversible, noncompetitive inhibitor of acethylcholinesterase and buthyrilcholinesterase, used for treatment of mild to moderate Alzheimer's disease. The aim was to investigate whether artificially IIAP in rats lowers their cognitive potential and Rivastigmine is able to diminish this disturbance using passive avoidance tests. Three groups of male Wistar rats were used: 1 st saline 0.1ml/100g body weight; 2 nd IIAP to 25mmHg; 3 rd IIAP + Rivastigmine 1 mg/kg. Step-through and step-down passive avoidance tests were performed in originally made apparatus by Ugo Basile, Italy. In both tests was observed the latency of reactionsfor the step-through time spend in the light chamber (178 seconds) and for the step-down time spend on the resting platform (60 seconds) of the apparatus. The rats with IIAP showed the latency of reaction similar than control group in both tests. In step-through test the group with model of IIAP and rivastigmine increased the latency of reaction on learning and long memory retention. In step-down tests the same group increased the latency only in long memory retention. It can be concluded that rivastigmine improves long term memory in rats with intra-abdominal and subsequent cerebral hypoxia.

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Attenuation of Oxidative Stress by Ischemic Preconditioning in an Experimental Model of Intraabdominal Hypertension

Cited by 8 publications

References 35 publications

Pneumoperitoneum preconditioning for the prevention of renal function after laparoscopic partial nephrectomy: protocol for a double-blind randomised controlled trial

Pneumoperitoneum preconditioning for the prevention of renal function after laparoscopic partial nephrectomy: protocol for a double-blind randomised controlled trial

Advances in Ischemia and Reperfusion

Effects of Rivastigmine on Behavioral Tests for Passive Training in Rats with Abdominal Hypertension

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