Michal Shatzky-Schwartz, Yaffa Hiller, Ziv Reich, Rodolfo Ghirlando, Sarah Weinberger, Abraham Minsky
Abstract:Inherently curved DNA segments, associated with short runs of adenines, have been identified in many gene regulatory regions, yet their physiological significance remains unknown. The observations reported in this study indicate that intrinsically bent nucleic acid fragments are characterized by substantially attenuated affinities toward DNA-binding proteins involved in structural functions, such as H1 histone and protamine, as well as toward various DNA-modifying enzymes including ligases and exo- and endonuc…
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