Attenuated Psychosis Syndrome: Don't Jump the Gun

Nelson, Barnaby

doi:10.1159/000365291

Cited by 19 publications

(21 citation statements)

References 27 publications

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“…In fact, UHR patients exhibit a considerable degree of other psychiatric outcomes as well as conversion to psychosis (van Os et al, 2001;Addington et al, 2011;Tsuang et al, 2013). The high rates of comorbidities suggest that distress in the UHR group may be associated with a range of presenting symptoms, not just APS, which is consistent with clinical impression at our UHR service and other UHR services Nelson, 2014). However, there has been no data published to date on the main sources of distress in the UHR population.…”

Section: Introductionsupporting

confidence: 52%

Sources of clinical distress in young people at ultra high risk of psychosis

Rapado-Castro

McGorry

Yung

et al. 2015

Schizophrenia Research

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Section: Introductionsupporting

confidence: 52%

Sources of clinical distress in young people at ultra high risk of psychosis

Rapado-Castro

McGorry

Yung

et al. 2015

Schizophrenia Research

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“…However, this has not been established in UHR cohorts, who are often in fact referred to clinical services for other non-psychotic complaints. 15 In this study, we aimed to examine whether the level of distress associated with attenuated psychotic symptoms predicts transition to psychotic disorder in the UHR population.…”

Section: Introductionmentioning

confidence: 99%

Distress in relation to attenuated psychotic symptoms in the ultra‐high‐risk population is not associated with increased risk of psychotic disorder

Power

Polari

Yung

et al. 2015

Early Intervention Psych

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Aim The ‘ultra‐high‐risk’ criteria identify a clinical population at substantially increased risk for progressing to schizophrenia and other psychotic disorders. Although a number of clinical variables predictive of transition to psychotic disorder have been identified within this population, the predictive value of the level of distress associated with attenuated psychotic symptoms has not yet been examined. This was the aim of the present study. Method The level of distress (0–100) associated with attenuated psychotic symptoms was recorded for 70 ultra‐high‐risk (UHR) patients using the Comprehensive Assessment of At‐Risk Mental State (CAARMS). Transition to psychosis was assessed over a 16‐month follow‐up period. Results Of the 70 UHR patients, 15 transitioned to psychosis (21.4%). Of the four CAARMS subscales measuring attenuated positive symptoms, Perceptual Abnormalities was rated as the most distressing. There were no differences in CAARMS scales rated as the most distressing between those who transitioned to psychosis and those who did not. There was also no association between higher levels of distress associated with attenuated psychotic symptoms and transition to psychosis. Conclusion Although the findings require replication, they indicate that the degree of distress associated with attenuated psychotic symptoms should not be used as a criterion for enriching UHR samples for risk of frank psychotic disorder.

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“…"The challenge in the years to come is to understand how the earliest expressions of psychopathology form part of a dynamic circuit of symptoms that affect and reinforce each other, gradually differentiating across stages of psychopathology into more specific, but still largely overlapping, clinical syndromes"; and it has been hypothesised that early psychopathology may evolve in many ways, which do not follow rigid train tracks to full blown mental disorders (1,7,16,17,(49)(50)(51).…”

Section: Discussionmentioning

confidence: 99%

Interpersonal sensitivity and persistent attenuated psychotic symptoms in adolescence

Masillo

Brandizzi

Valmaggia

et al. 2017

Eur Child Adolesc Psychiatry

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Interpersonal sensitivity defines feelings of inner-fragility in the presence of others due to the expectation of criticism or rejection. Interpersonal sensitivity was found to be related to attenuated positive psychotic symptom during the prodromal phase of psychosis. The aims of this study were to examine if high level of interpersonal sensitivity at baseline are associated with the persistence of attenuated positive psychotic symptoms and general psychopathology at 18-month follow-up. A sample of 85 help-seeking individuals (mean age = 16.6, SD = 5.05) referred an Italian early detection project, completed the interpersonal sensitivity measure and the structured interview for prodromal symptoms (SIPS) at baseline and were assessed at 18-month follow-up using the SIPS. Results showed that individuals with high level of interpersonal sensitivity at baseline reported high level of attenuated positive psychotic symptoms (i.e., unusual thought content) and general symptoms (i.e., depression, irritability and low tolerance to daily stress) at follow-up. This study suggests that being "hypersensitive" to interpersonal interactions is a psychological feature associated with attenuated positive psychotic symptoms and general symptoms, such as depression and irritability, at 18-month follow-up. Assessing and treating inner-self fragilities may be an important step of early detection program to avoid the persistence of subtle but very distressing long-terms symptoms.

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Attenuated Psychosis Syndrome: Don't Jump the Gun

Cited by 19 publications

References 27 publications

Sources of clinical distress in young people at ultra high risk of psychosis

Sources of clinical distress in young people at ultra high risk of psychosis

Distress in relation to attenuated psychotic symptoms in the ultra‐high‐risk population is not associated with increased risk of psychotic disorder

Interpersonal sensitivity and persistent attenuated psychotic symptoms in adolescence

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