Attenuated Auditory Event-Related Potential (Mismatch Negativity) in Children with Developmental Dysphasia

Abstract

An attention-independent negative wave-form termed 'mismatch negativity' (MMN) of the auditory event-related potentials (ERPs) was studied in ten children (3-6 years) with developmental dysphasia and in fourteen control children (3-7 years) with normal speech and language development. The MMNs were elicited with pure sine tone stimuli using the oddball paradigm. The peak latency and peak amplitude of MMN response to frequency (500/553 H2) difference was measured. The grand average amplitude of frequency MMN was significantly attenuated in dysphasic children as compared to controls, but no significant difference was observed in the latency of peak frequency MMN. The results indicate that dysphasic children have a defect in automatic auditory processing of frequency differences. Because the MMN response reflects central auditory processing and is modal specific for auditory stimuli we argue that the MMN method can serve as an objective tool to assess central auditory deficits in children.

Neural plasticity following auditory training in children with learning problems

“…Relationships between evoked potentials, auditory processing and speech perception have been shown for children with language impairment (Tonnquist-Uhlen, 1996), dyslexia (Bakker and Vinke, 1985;McPherson and Ackerman, 1999), dysphasia (Holopainen et al, 1997), spelling disabilities (Byring and Jarvilehto, 1985), auditory processing disorders (Jirsa and Clontz, 1990) and learning problems (Kraus et al, 1996;Cunningham et al, 2000;King et al, 2002;Wible et al, 2002).…”

O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

“…In this study, MMN was normal for speech stimuli deviating in terms of the articulation point. 18 The investigation of MMN in (C)APD patients with associated comorbidities due to other diseases shows that MMN was altered for speech stimuli but normal for pure tone stimuli in some studies, [19][20][21][22] that MMN was altered for verbal and non-verbal stimuli in other studies, 23 still others in which MMN was altered for pure tone stimuli with frequency deviations, [24][25] studies in which MMN was altered for pure tones with frequency but not duration deviations, [26][27] studies in which MMN was normal for pure tones with frequency deviations but altered for different compound tone patters, 28 and in studies in which MMN was unchanged for frequency and duration stimuli. [29][30][31][32] Our study aimed to investigate MMN in (C)APD patients, considering the diversity of results in studies of MMN in these patients, as well as the importance of undertaking the electrophysiological evaluation of auditory processing studies.…”

Aplicabilidade do Mismatch Negativity na população infantil: revisão sistemática de literatura

“…The oldest publication was from 1997 (39) and the most recent one from 2015 (4) . Regarding the language of publication, it was verified that 3 articles were published in Portuguese.…”

“…were written in the English language and no studies were written in Spanish. Regarding the place of publication, most articles, totaling 6 (21,28,35,36,38,39) , were developed in Finland. Three articles were written in Brazil (4,12,19) , 3 in the Netherlands (20,23,25) , 3 in the United States (31,32,34) and 3 in France (26,29,30) .…”

“…The participants' ages ranged from 2 months (23) to 12 years of age (4,12,19,22,35,37) . Regarding the parameters used to perform the MMN, most of the research used the speech stimulus (4,(20)(21)(22)(23)(24)(25)(26)30,(32)(33)(34)(35)(36) and other studies opted to perform the MMN with tone burst stimulus (12,19,22,(27)(28)(29)31,(37)(38)(39) . Regarding the tone burst stimulus, it was verified that some studies evaluated with frequency variation (12,(27)(28)(29)31,(37)(38)(39) and 1, by duration and frequency (19) .…”