Attention deficit disorder in children

Voeller, Kytja K. S.; Heilman, Kenneth M.

doi:10.1212/wnl.38.5.806

Cited by 124 publications

(81 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The asymmetry of human spatial attention is well documented in both disease and healthy states: right-hemisphere (RH) lesions are more frequently associated with hemispatial neglect compared with left-hemisphere (LH) lesions and usually cause more severe and persistent deficits (Mesulam, 1999); moreover, a leftward bias in the perception of length, size, brightness, and numerosity, termed right "pseudoneglect," is frequently reported in healthy subjects (Orr and Nicholls, 2005); and finally, left-rather than right-sided inattention has been reported in patients with attention deficit disorder (ADD) (Voeller and Heilman, 1988) and developmental dyslexia (Hari et al, 2001;Sireteanu et al, 2005). A recent report of a leftward attention bias in birds (Diekamp et al, 2005) suggests a fundamental evolutionary role for this bias.…”

Section: Introductionmentioning

confidence: 99%

Bihemispheric Leftward Bias in a Visuospatial Attention-Related Network

Siman-Tov¹,

Mendelsohn²,

Schönberg³

et al. 2007

J. Neurosci.

119

View full text Add to dashboard Cite

Asymmetry of spatial attention has long been described in both disease (hemispatial neglect) and healthy (pseudoneglect) states. Although right-hemisphere specialization for spatial attention has been suggested, the exact neural mechanisms of asymmetry have not been deciphered yet. A recent functional magnetic resonance imaging study from our laboratory serendipitously revealed bihemispheric left-hemifield superiority in activation of a visuospatial attention-related network. Nineteen right-handed healthy adult females participated in two experiments of visual half-field presentation. Either facial expressions (experiment 1) or house images (experiment 2) were presented unilaterally and parafoveally for 150 ms while subjects were engaging a central fixation task. Brain regions previously associated with a visuospatial attention network, in both hemispheres, were found to be more robustly activated by left visual field stimuli. The consistency of this finding with manifestations of attention lateralization is discussed, and a revised model based on neural connectivity asymmetry is proposed. Support for the revised model is given by a dynamic causal modeling analysis. Unraveling the basis for attention asymmetry may lead to better understanding of the pathogenesis of attention disorders, followed by improved diagnosis and treatment. Additionally, the proposed model for asymmetry of visuospatial attention might provide important insights into the mechanisms underlying functional brain lateralization in general.

show abstract

Section: Introductionmentioning

confidence: 99%

Bihemispheric Leftward Bias in a Visuospatial Attention-Related Network

Siman-Tov¹,

Mendelsohn²,

Schönberg³

et al. 2007

J. Neurosci.

119

View full text Add to dashboard Cite

show abstract

“…A number of studies have reported the presence of attentional asymmetries in ADHD using both clinical and experimental measures of attention (Voeller and Heilman, 1988;Carter et al, 1995;Nigg et al, 1997;McDonald et al, 1999;Sheppard et al, 1999). Failure to replicate these effects in some studies (Wood et al, 1999;Klimkeit et al, 2003), nevertheless, suggests neuropsychological heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Association between Dopamine Transporter (DAT1) Genotype, Left-Sided Inattention, and an Enhanced Response to Methylphenidate in Attention-Deficit Hyperactivity Disorder

Bellgrove

Hawi

Kirley

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the attention deficit in ADHD includes a subtle inattention to left space, resembling that seen after right cerebral hemisphere damage. Since left-sided inattention in ADHD may resolve when treated with MPH, we asked whether left-sided inattention in ADHD was related to DAT1 genotype and the therapeutic efficacy of MPH. A total of 43 ADHD children and their parents were genotyped for the DAT1 3 0 variable number of tandem repeats polymorphism. The children performed the Landmark Test, a well-validated measure yielding a spatial attentional asymmetry index (leftward to rightward attentional bias). Parents rated their child's response to MPH retrospectively using a three-point scale (no, mediocre or very good response). Additionally, parents used a symptom checklist to rate behavior while on and off medication. A within-family control design determined whether asymmetry indices predicted biased transmission of 10-repeat parental DAT1 alleles and/or response to MPH. It was found that left-sided inattention predicted transmission of the 10-repeat allele from parents to probands and was associated with the severity of ADHD symptomatology. Children rated as achieving a very good response to MPH displayed left-sided inattention, while those rated as achieving a poorer response did not. Our results suggest a subgroup of children with ADHD for whom the 10-repeat DAT1 allele is associated with left-sided inattention. MPH may be most efficacious in this group because it ameliorates a DAT1-mediated hypodopaminergic state.

show abstract

“…Results of many investigations suggest that the problems in ADHD may be due to a lateralised disturbance in the frontal lobe network function, mediated by the under activity of predominantly the right hemispheric frontostriatal regions (9,32,33,34). Functional neuroimaging studies, using single photon emission computed thomography (SPECT), positron emission thomography (PET) and functional magnetic resonance imaging (fMRI) have identified anomalies of frontal metabolic activity indexed by diminished cerebral blood flow or glucose metabolism (5,32,35).…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have shown an association between the diagnosis of childhood ADHD and a relative reduction in awareness for visual information presented on the left (6,7,8,9). Normally, visual stimuli evoke predominantly right hemisphere activity, so that attention is directed preferentially to the left.…”

mentioning

confidence: 99%

An investigation of visual-spatial attention in children with attention deficit hyperactivity disorder Dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda görsel-uzaysal dikkatin araştırılması

Emel¹

2005

Ankara Üniversitesi Tıp Fakültesi Mecmuası

View full text Add to dashboard Cite

Aim: Attention deficit hyperactivity disorder (ADHD ) has been associated with a disturbance in frontal lobe network function, mediated by the underactivity of right hemispheric frontostriatal regions and loss of normal functional asymmetry. The aim of this study was to examine the right hemisphere functions and lateralization of visual-spatial attention in ADHD, using line bisection task. Materials and Methods: Eighteen children with a DSM IV diagnosis of ADHD participated with 18 healthy controls, individually matched for age, sex, handedness and school years. In the line bisection task, horizontal lines were presented on the computer screen. Half of the lines were presented in the right hemispatial area, and half in the left hemispatial area. Participants were instructed to move the vertical cursor to the judged center of the line by mouse. Subjects performed the task separately with each hand. The difference between fine motor performances was examined using finger tapping task. Results: In the line bisection task, bisection performance of the children with ADHD was significantly lower than that of the normal children. For mean bisection error scores, the controls were transecting the lines to the left of the center when the lines were presented in the left hemispace and to the right of the center when the lines were presented in the right hemispace, performing both hands. The subjects with ADHD showed the same but smaller bias than the controls. The apparent deviations from the actual center in the children with ADHD were not significantly different from zero in all conditions. In the finger tapping task, there were no significant differences between two groups for both hands. Conclusion: These results supported the evidence for deficit in visual-spatial attention consistent with disability of the right hemisphere in ADHD.Key words: attention deficit hyperactivity disorder, line bisection task, spatial attention, right cerebral hemisphere Amaç: Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB)'nun sağ fronto-striatal devreyi ilgilendiren bir bozukluğun sonucu olduğu iddia edilmektedir. Bu çalışmada çizgi bölme testi kullanılarak DEHB'de sağ hemisfer işlevlerinin ve görsel uzaysal dikkatin asimetrisinin incelenmesi amaçlan-mıştır. Gereç ve Yöntem: DSM-IV ölçütlerine göre DEHB tanısı almış, ilaç kullanmayan ve eşlik eden başka nörolojik veya psikiyatrik bozukluğu olmayan 7-14 yaşları arasında sağ elini kullanan 18 çocuk ile onlarla yaş, cinsiyet, el tercihi ve okul yaşı açısından bire bir eşleştirilmiş 18 sağlıklı çocuk araştırmaya dahil edildi. Bütün çocuklar çizgi bölme testini sağ ve sol elleri ile bilgisayar faresi kullanarak yaptılar. Bilgisayar ekranının yatay olarak sağından ve solundan sunulan çizgilerin tam orta noktalarını işaretlemeleri istendi. Ayrıca her iki gruptaki çocukların ince motor yetenekler açısından farkları parmak vuru testi ile değerlendirildi. Bulgular: DEHB olan çocuklar çizgi bölme testinde anlamlı olarak daha çok mutlak hata yaparak kontrol grubuna göre düşük bir performans gösterdi...

show abstract

Attention deficit disorder in children

Cited by 124 publications

References 0 publications

Bihemispheric Leftward Bias in a Visuospatial Attention-Related Network

Bihemispheric Leftward Bias in a Visuospatial Attention-Related Network

Association between Dopamine Transporter (DAT1) Genotype, Left-Sided Inattention, and an Enhanced Response to Methylphenidate in Attention-Deficit Hyperactivity Disorder

An investigation of visual-spatial attention in children with attention deficit hyperactivity disorder Dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda görsel-uzaysal dikkatin araştırılması

Contact Info

Product

Resources

About