Atrial natriuretic peptide inhibits tumor necrosis factor-alpha production by interferon-gamma-activated macrophages via suppression of p38 mitogen-activated protein kinase and nuclear factor-kappa B activation

Tsukagoshi, Hideo; Shimizu, Yasuo; Kawata, Takefumi; Hisada, Takeshi; Shimizu, Yūji; Iwamae, Shigenori; Ishizuka, Tamotsu; Iizuka, Kunihiko; Dobashi, Kunio; Mori, Masataka

doi:10.1016/s0167-0115(01)00218-x

Cited by 52 publications

(43 citation statements)

References 54 publications

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“…Antiproliferative and anti-hypertrophic effects of the ANP/NPRA system have been reported to be mediated through the generation of cGMP (3,12,21,25,33). Furthermore, ANP/NPRA/cGMP signaling have been shown to oppose the hypertrophic agonist such as Ang II and ET-1 mediated biological effects (14,29). Hypertrophic agonist such as angiotensin II and norepinephrine, have been shown to mediate hypertrophic responses in neonatal and adult myoctes by activating IL-6 and TGF-β1 genes (7,27).…”

Section: Discussionmentioning

confidence: 99%

“…Hypertrophic agonist such as angiotensin II and norepinephrine, have been shown to mediate hypertrophic responses in neonatal and adult myoctes by activating IL-6 and TGF-β1 genes (7,27). Additionally, recent evidences suggest that ANP/NPRA system has anti-inflammatory activity, and reported to inhibit the bacterial toxin (LPS) and IFN-gamma-induced pro-inflammatory cytokines expression in macrophages by suppressing signal transduction pathway leading to NF-κB activation (29,32). It has been suggested that ANP plays important role in regulating inflammatory signaling in endothelial cells, leading to reduced TNF-α-induced expression of adhesion molecules (11).…”

Section: Discussionmentioning

confidence: 99%

“…However, it can be suggested that NF-κB-mediated signaling is involved in the synthesis of pro-inflammatory cytokines in mice lacking NPRA. ANP/NPRA/cGMP signaling attenuates the production of inflammatory mediators such as TNF-α by regulating the NF-κB pathway (29,32). Furthermore, ANP and cGMP analogues have been reported to suppress NF-κB activation by inhibiting the phosphorylation of IκB-α and its subsequent degradation in cultured cells (11).…”

Section: Discussionmentioning

confidence: 99%

“…Atrial natriuretic peptide (ANP) has been shown to inhibit the TNF-α induced adhesion molecule expression in endothelial cells (32). ANP has also been shown to inhibit TNF-α production in interferon-gamma-activated macrophages (29).…”

Section: Introductionmentioning

confidence: 99%

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Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A

2007

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Natriuretic peptide receptor-A (NPRA) is the principal receptor for the cardiac hormones ANP and BNP. Mice lacking NPRA develop progressive cardiac hypertrophy and congestive heart failure. However, the mechanisms responsible for hypertrophic growth in the absence of NPRA signaling are not yet known. In the present study, we determined whether deficiency of NPRA/cGMP signaling alters the cardiac pro-inflammatory cytokines gene expression in Npr1 (coding for NPRA) geneknockout (Npr1 −/− ) mice exhibiting cardiac hypertrophy and fibrosis as compared with control wildtype (Npr1 +/+ ) mice. A significant up-regulation of cytokine genes such as TNF-α (5-fold), IL-6 (3-fold) and TGF-β1 (4-fold) were observed in mutant mice hearts lacking NPRA as compared with the age-matched wild-type mice. In parallel, NF-κB binding activity was almost 5-fold greater in the nuclear extract of Npr1 −/− mutant mice hearts as compared with wild-type Npr1 +/+ mice hearts. Guanylyl cyclase (GC) activity and cGMP levels were drastically reduced by 10-fold and 6-fold, respectively, in ventricular tissues of mutant mice hearts relative to wild-type controls. The present findings provide direct evidence that ablation of NPRA/cGMP signaling activates inflammatory cytokines, probably via NF-κB mediated signaling pathway, and is associated with hypertrophic growth of null mutant mice hearts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A

2007

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“…The level of transcription and synthesis of TNF-is controlled by two factors: Activation protein 1 (AP-1) and Nuclear factor kappa B (NF-κB) (Rhoades et al,1992), and ANP inhibits their activation by cGMP mediated pathways (Tsukagoshi et al, 2001;Kiemer & Vollmar, 2001). Furthermore, NF-κB and Nuclear Factor of Activated T cells (NFAT) control transcription of the gene for IFN-and hence the synthesis IFN- (Sica et al, 1997).…”

Section: Immunomodulatory Role Of Anp In Preovulatory Folliclementioning

confidence: 99%

Ovarian Biomarkers in Infertility

Vangelov¹,

Dineva²,

Todorova³

et al. 2012

Trends in Immunolabelled and Related Techniques

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The “drunken honeycomb” feature of pulmonary mucinous adenocarcinoma: A diagnostic pitfall of bronchial brushing cytology

Morency

Urrego

Szporn

et al. 2011

Diagnostic Cytopathology

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Pulmonary mucinous adenocarcinoma (PMA) is the terminology recently proposed in the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) International Multidisciplinary Classification of Lung Adenocarcinoma Guidelines for most tumors previously classified as mucinous bronchioloalveolar carcinomas (mBACs). PMA is histologically characterized by lepidic growth and at least some degree of invasive growth of goblet or columnar neoplastic cells with abundant intracytoplasmic mucin. We report here the cytologic features of PMA in a bronchial brushing specimen. The patient is an 84-year-old woman with a persistent dense consolidation in the right middle lobe of the lung found on non-contrast computed tomography (CT) scan. Bronchial brushing smears showed a monotonous population of columnar neoplastic cells forming "drunken honeycomb"-like cell clusters. The neoplastic cells displayed inconspicuous cytologic atypia. The concurrent transbronchial tissue biopsy and the resection specimen confirmed the diagnosis of PMA. Due to the bland nuclear features, the neoplastic cells in the bronchial brushing specimen were interpreted as benign at the time of the initial diagnosis, demonstrating a diagnostic pitfall of bronchial brushing cytology. A high index of suspicion is recommended when a lung lesion with "drunken honeycomb"-like cell clusters is encountered in bronchial brushing specimens. The review of the literature regarding the recently designated PMA is presented.

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Atrial natriuretic peptide inhibits tumor necrosis factor-alpha production by interferon-gamma-activated macrophages via suppression of p38 mitogen-activated protein kinase and nuclear factor-kappa B activation

Cited by 52 publications

References 54 publications

Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A

Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A

Ovarian Biomarkers in Infertility

The “drunken honeycomb” feature of pulmonary mucinous adenocarcinoma: A diagnostic pitfall of bronchial brushing cytology

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