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Cited by 134 publications
(133 citation statements)
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“…It is thought that ATR-ATRIP, as part of the DNA replication machinery, associated with RPA, monitors single stranded DNA damage during the progression of DNA replication fork elongation (Niida and Nakanishi, 2006;Shechter et al, 2004b). In addition, ATR functions in both S and M phases include regulating late DNA replication origin firing, replication fork elongation, restarting stalled replication forks and involvement in centrosome stability (Shechter et al, 2004a;Cha and Kleckner, 2002;Sorensen et al, 2004;Friedel et al, 2009;Alderton et al, 2004;Smith et al, 1998).…”
Section: Atr Activation In Response To Single Strand Dna Damagementioning
confidence: 99%
“…It is thought that ATR-ATRIP, as part of the DNA replication machinery, associated with RPA, monitors single stranded DNA damage during the progression of DNA replication fork elongation (Niida and Nakanishi, 2006;Shechter et al, 2004b). In addition, ATR functions in both S and M phases include regulating late DNA replication origin firing, replication fork elongation, restarting stalled replication forks and involvement in centrosome stability (Shechter et al, 2004a;Cha and Kleckner, 2002;Sorensen et al, 2004;Friedel et al, 2009;Alderton et al, 2004;Smith et al, 1998).…”
Section: Atr Activation In Response To Single Strand Dna Damagementioning
confidence: 99%
“…It also promotes DNA repair and the stabilization of stalled replication forks (1). In Saccharomyces cerevisiae, Mec1 is the PI3K-like kinase that initiates the signal transduction network leading to checkpoint activation, cell cycle arrest, and the up-regulation of DNA repair (2,3). Mec1 forms a constitutive heterodimer with its regulatory subunit Ddc2.…”
mentioning
confidence: 99%
“…Mec1 forms a constitutive heterodimer with its regulatory subunit Ddc2. The generation of single-stranded DNA coated with the single-stranded binding protein RPA 3 is a critical step in the recruitment of Mec1 to sites of damage, which is mediated through Ddc2-RPA interactions (4,5). One or more Mec1 activators are also recruited to these sites, and the juxtaposition on chromatin of a given activator with Mec1 results in the activation of Mec1 protein kinase activity (6) and the phosphorylation of a large number of proteins, including RPA, subunits of the 9-1-1 checkpoint clamp, mediator proteins, and downstream effector kinases such as Rad53.…”
mentioning
confidence: 99%
“…Activated Chk1 phosphorylates its downstream substrate Cdc25a (refs 7,8), thus destabilizing it, to prevent the firing of later origins 9 . This process is essential in establishing the S-phase checkpoint to block replication fork progression, whereas deficiency of ATR or Chk1 abolishes this checkpoint and causes cellular and organismal lethality [10][11][12][13][14][15][16][17] . Although ATR and its upstream partners have been mapped to damaged replication forks, how Chk1 is activated by upstream kinases in the vicinity of these replication forks remains rather speculative.…”
mentioning
confidence: 99%