Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate

Zhang, Ning; Huan, Yi; Huang, Hui; Song, Guangming; Sun, Sujuan; Shen, Zhufang

doi:10.1038/aps.2009.176

Cited by 29 publications

(22 citation statements)

References 31 publications

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“…57 In spite of that, our MSG mice did not display altered serum cytokine levels as compared with lean controls, corroborating a previous study which showed that 6-month-old MSG mice had higher hepatic but unaltered serum levels of TNFα and IL-6. 58 Indeed, MSG rodents have hypercorticosteronemia, 59 which suppresses systemic pro-inflammatory cytokines production. 60 However, MSG rodents also have resistance to corticosterone in adipose tissue, 61 and corticosterone excess can induce oxidative stress 62 and lipid accumulation 63 in hepatocytes, which might explain the paradoxical inflammation upon these tissues.…”

Section: Discussionmentioning

confidence: 99%

Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice

Coêlho

França

Nascimento

et al. 2018

J Dev Orig Health Dis

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Monosodium l-glutamate (MSG)-induced obesity is a useful model for non-alcoholic fatty liver disease (NAFLD) studies. However, there is limited data on its initiation and progression. Thus, this study aimed to characterize the onset of metabolic and histopathological features of NAFLD and its progression to non-alcoholic steatohepatitis (NASH) in this model. To perform this study, Swiss mice pups were neonatally injected with MSG (4 g/kg/day, s.c.) or equiosmolar saline and followed up to 60, 120 or 180 days old. At each age, blood, liver, as well as periepididymal and retroperitoneal fat pads were collected for morphometric, biochemical and histological analyses, the later according to NAFLD activity score. MSG mice presented hypertriglyceridemia and central obesity at all ages, but peripheral insulin-resistance was verified only in 120- and 180-day-old mice. Hepatic total fat and triglycerides content were higher in MSG mice at all ages. Accordingly, histopathological analysis showed that 60-day-old MSG mice had microvesicular steatosis with occasional ballooning, which evolved into NASH from 120 days old. Retroperitoneal fat accumulation was the only variable to independently correlate with NAFLD activity total score upon multivariate analysis (R 2=71.45%). There were no differences in IL-6 and TNF-α serum levels among groups. Overall, this study shows that NAFLD is a precocious outcome in MSG-obese mice, whereas the period comprised between 60 and 120 days old seems to be a crucial metabolic window for comprehending pathophysiological events involved in NAFLD-to-NASH progression in this model.

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Section: Discussionmentioning

confidence: 99%

Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice

Coêlho

França

Nascimento

et al. 2018

J Dev Orig Health Dis

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“…Further, the beneficial effects of pioglitazone have been primarily observed on triglycerides in both animal [ 19 ] and humans [ 20 , 21 ] with minimal effects on other lipid components [ 20 , 21 ]. Similarly, the lipid lowering effects of atorvastatin in rats and mice have consistently been documented only on triglycerides [ 10 , 22 , 23 ]. Also, in most studies statins do not decrease LDL levels in these animals.…”

Section: Discussionmentioning

confidence: 99%

Postprandial Hypertriglyceridemia Predicts Development of Insulin Resistance Glucose Intolerance and Type 2 Diabetes

et al. 2016

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Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) have been found to be associated with postprandial hypertriglyceridemia (PPHTg). However, whether PPHTg can cause IR and diabetes is not clear. We therefore investigated the role of PPHTg in development of T2DM in rat model of T2DM. 96 male Wistar rats were randomized into four groups (24 rats each). Control Group A, high sucrose diet (HSD) Group B, HSD+Pioglitazone (10mg/kg/day) Group C and HSD+Atorvastatin (20mg/kg/day) Group D. Fat and glucose tolerance tests were done at regular intervals in all groups besides insulin and body weight measurement. At 26 weeks, low dose streptozotocin (15mg/kg,i.p.) was given to half of the rats. All rats were followed up till 48 weeks. PPHTg developed as early as week 2 in Group B and stabilized by week 14. Group B displayed highest PPHTg compared to other groups. Atorvastatin treatment (Group D) abolished PPHTg which became comparable to controls, pioglitazone treatment partially blunted PPHTg resulting in intermediate PPHTg. Group B with highest PPHTg showed highest subsequent IR, glucose intolerance (GI) and highest incidence of prediabetes at week 26 and diabetes at week 34 and 46 compared to other groups. Group D rats displayed lower IR, GI, low incidence of prediabetes and diabetes at these time points compared to Groups B and C. ROC analysis showed that triglyceride area under the curve of each time point significantly predicts the risk of diabetes. Present study provides the evidence that PPHTg predicts the development of IR, GI and T2DM in rat model of diet induced T2DM.

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“…MSG increases insulin resistance and thereby increases blood insulin level, blood glucose plasma levels and also an increase in the plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and free fatty acid levels. It also reduces the cortisol induced lipolysis (Zhang et al, 2010).…”

Section: Bioscience Biotechnology Research Communicationsmentioning

confidence: 99%

Effect of monosodium glutamate on striato-hippocampal acetylcholinesterase level in the brain of male Wistar albino rats and its implications on learning and memory during aging

Sreejesh¹,

Sreekumaran²

2018

Biosci. Biotech. Res. Comm

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Glutamate is one of the most abundant excitatory neurotransmitters of brain, plays an important role in learning and memory. Monosodium glutamate (MSG) is a sodium salt of L-glutamate, a well-known fl avor enhancer. Because of its capacity to increase the palatability, nowadays it is most widely used in all households and fast foods. The present study investigates the effect of MSG on striato-hippocampal acetylcholinesterase (AChE) level in the brain of male wistar albino rats and its implications on learning and memory during aging. The experimental groups consisted of 3-4 weeks old Wistar albino rats and were divided into group I and group II. These groups were again subdivided into control group treated with laboratory diet, 100 mg MSG, 400 mg MSG, 2 g MSG and 4 g MSG group treated with various doses of MSG/ kg body weight for sixty days. Immediately after 60 days of MSG treatment, the group I was used for the analysis of body weight, T-maze test, novel object recognition test (NOR) and AChE level while group II was kept free of MSG for further sixty days and later used for the above experiments. The results showed that group I animals neither have a dose dependent increase in body weight, a decline in the T-maze response, reduced discrimination index in NOR test and an increase in AChE level. However, the changes were signifi cant at 4 g MSG treated group. The group II animals did not showed any signifi cant differences when compared to control group. Thus the study revealed that a long term administration of MSG has a capacity to cause cognitive impairment but is not perpetual, during the life time, due to normal diet and natural healing mechanisms in the body ameliorates the toxic effects of MSG and showed gradual increase in the cognitive parameters, however it take a long time.

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Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate

Cited by 29 publications

References 31 publications

Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice

Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice

Postprandial Hypertriglyceridemia Predicts Development of Insulin Resistance Glucose Intolerance and Type 2 Diabetes

Effect of monosodium glutamate on striato-hippocampal acetylcholinesterase level in the brain of male Wistar albino rats and its implications on learning and memory during aging

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