Atopic dermatitis in adults and irritable bowel syndrome: A cross-sectional study

Abstract

Background:Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people in the world. Atopic dermatitis (AD) is a common inflammatory skin condition characterized by relapsing eczematous lesions in a typical distribution. It was first described in 1933 but exists since antiquity.Aim and Objectives:To determine the relationship between AD and IBS.Materials and Methods:A total of 109 patients with AD and 100 healthy controls were included in the study. They were defined for diagnosis of IBS according to ROME-III diagnostic criteria. Supporting findings, Bristol stool scale, frequency of defecation and history of AD and IBS were also evaluated. AD severity was assessed using Severity Scoring of Atopic Dermatitis index.Results:A total of 62 patients (56.9%) in the AD group and 28 patients (28%) in the control group were diagnosed with IBS (P<0.001). Supportive findings excluding abnormal stool frequency and passage of mucus were more frequent in AD patients. There was no significant relationship between disease severity according to SCORAD index and variables in AD patients.Conclusions:This is a rather uncultivated area in the field of AD. We observed that IBS was more common in AD group. Also, supporting findings like abnormal stool form, abdominal distension, feeling of incomplete evacuation, and straining were found more frequently in AD patients. These results may indicate the association between AD and IBS. In our opinion, patients with atopic dermatitis should be questioned in terms of IBS.

Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data

“…However, since the exact prevalence of each of the diagnoses included in the visual impairment EDC was unavailable, we were unable to contrast their results with our own. Our results for irritable bowel syndrome (1.90 (1.56-2.31)) were consistent with other recently published studies on children and adults with AD [41,42].…”

Skin manifestations associated with irritable bowel syndrome

“…However, there are conflicting results depending on studies. 4 Some reports found significant higher prevalence of IBS in atopic dermatitis (AD) patients compared with controls 5 and higher risk to develop IBS in children suffering from AD. 6 On the other hand, atopic disease was found to be slightly increased in patients with IBS compared to control but without reaching statistical significance.…”

Effect of acupuncture treatment in patients with mild to moderate atopic dermatitis: a randomized, participant- and assessor-blind sham-controlled trial

“…Recently, atopic diseases have been reported to be associated with functional GI disorders such as functional dyspepsia and irritable bowel syndrome [ 15 ]. Moreover, adults with AD had higher odds of developing gastroenteritis than those without AD [ 33 , 34 ]. In this study, we found the GI function such as dyspepsia and gastric discomfort correlated with AD symptoms (SCORAD).…”