Atopic dermatitis exacerbated by inhalant allergens

Burges, G. E.

doi:10.1001/archderm.123.11.1437

Cited by 10 publications

(5 citation statements)

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“…in contrary to allergic asthma and allergic rhinitis, in which the causative allergens can be often found out by means of skin tests, specific IgE deter mination by RAST or specific inhalative provocation tests, allergens causing or worsening the skin conditions can be seldom detected in AD [4], However, a seasonal occur rence or exacerbation in spring, with a periocular localiza tion (atopic eyelid eczema), also in case of AD without R A (so-called 'pure' AD), is a good indicator for a causal importance of pollen allergens, as shown by Tuft [6]. Storck [7], recently by Burges and Lang [8] and confirmed by our first case report. Storck [7] proposed the appropri ate term of AD as a 'hay fever equivalent'.…”

Section: Discussionmentioning

confidence: 99%

“…The IgE response is so far a faculta tive attribute of AD and according to Hanifin and Rajka [ 17] only a minor diagnostic criterion. In the practice and for further research three main types of AD could be dis tinguished [11]: a 'mixed' type in the case of AD with con comitant respiratory allergies (in this type an almost poly valent IgE sensitization against inhalants and foodstuffs is obligatory [8]) and a 'pure' AD without respiratory dis eases. in order to eliminate the immunological and phar macological abnormalities related to the atopic airways allergies.…”

Section: Discussionmentioning

confidence: 99%

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Atopic Dermatitis Flare Provoked by Inhalant Allergens

Wüthrich¹

1989

Dermatology

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We report on 2 patients with atopic dermatitis (AD) exacerbated by inhalant allergens: grass pollens in spring (AD as hay fever equivalent) and nonbiting red midges (chironomides) in pet fish food. These clinical observations confirm the existence of an ‘extrinsic’ IgE-mediated type of AD in a minority of patients in which the IgE sensitization against specific allergens plays a causal role for the skin disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atopic Dermatitis Flare Provoked by Inhalant Allergens

Wüthrich¹

1989

Dermatology

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“…There has been no clear consensus that aeroallergens are important in the pathogenesis of AD; however, several studies have found a role of aeroallergens, especially house‐dust mite, in the pathogenesis of AD (4–6). There is evidence that the homes of patients with AD have a higher level of exposure to house‐dust mite than the homes of controls (7).…”

Section: Atopic Dermatitis and Aeroallergensmentioning

confidence: 99%

Atopy patch testing – a diagnostic tool?

Bruin‐Weller¹,

Knol²,

Bruijnzeel-Koomen³

1999

Allergy

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“…those of grass pollen and house-dust mites, induce eczematous reactions when applied to the skin (4,11,31). Moreover, it was shown that skin contact with these allergens may result in a general exacerbation of AD (1,5,17,26,36).…”

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confidence: 99%

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

Kapp

1993

Allergy

156

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Currently, there is a large body of evidence that atopic dermatitis (AD) has an Immunologic basis. Atopy‐specific helper T cells (Th2‐like T cells) may play a pathogenetic role by producing and releasing cytokines relevant for the allergic inflammation, such as IL‐4, IL‐5, and other growth factors. Eosinophils are believed to be of major importance as effector cells mediating the pathogenetically relevant late‐phase reaction which is associated with a significant destruction of the surrounding tissue. Accordingly, a significant preactivation of peripheral blood eosinophils was detected in AD patients, leading to an enhanced susceptibility of these cells to distinct stimuli such as IL‐5. Toxic proteins, such as eosinophil cationic protein (ECP), contained in the matrix and the core of secondary granules of eosinophils, may play an important role by propagating the allergic inflammatory process and by modulating the immune response. The pathogenetic role of eosinophils in AD is further supported by the detection of these proteins in the eczematous skin of patients. Furthermore, recent data point to a significant correlation between disease activity and deposition of eosinophil granule content: ECP serum levels were significantly increased in AD patients. In addition, ECP levels correlated with the disease activity. Moreover, clinical improvement was associated with a decrease of both the clinical score and serum ECP levels. These data clearly indicate that activated eosinophils may play a major role in the allergic inflammatory process of AD. Therefore, modulation of eosinophil activation could prove to be an important pharmacologic modality for the treatment of AD.

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Atopic dermatitis exacerbated by inhalant allergens

Cited by 10 publications

References 0 publications

Atopic Dermatitis Flare Provoked by Inhalant Allergens

Atopic Dermatitis Flare Provoked by Inhalant Allergens

Atopy patch testing – a diagnostic tool?

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

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