2012
DOI: 10.3390/s120608278
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Abstract: This review article discusses and documents the basic concepts and principles of nano/biosensors. More specifically, we comment on the use of Chemical Force Microscopy (CFM) to study various aspects of architectural and chemical design details of specific molecules and polymers and its influence on the control of chemical interactions between the Atomic Force Microscopy (AFM) tip and the sample. This technique is based on the fabrication of nanomechanical cantilever sensors (NCS) and microcantilever-based bios… Show more

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Cited by 71 publications
(26 citation statements)
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“…This system was calibrated after the chamber was¯lled with PBS. The measurements were performed as follows: each assay consisted of 1 mL of enzyme solution, with di®erent concentrations (2,11,17,25,85,141, and 249 ng mL À1 ) being tested. Unspeci¯c interactions were also evaluated by the addition of glucose oxidase enzyme (249 ng mL À1 ) into the system.…”
Section: Liquid Cell Devicementioning
confidence: 99%
See 1 more Smart Citation
“…This system was calibrated after the chamber was¯lled with PBS. The measurements were performed as follows: each assay consisted of 1 mL of enzyme solution, with di®erent concentrations (2,11,17,25,85,141, and 249 ng mL À1 ) being tested. Unspeci¯c interactions were also evaluated by the addition of glucose oxidase enzyme (249 ng mL À1 ) into the system.…”
Section: Liquid Cell Devicementioning
confidence: 99%
“…1,9 In dynamic mode, detection is performed through monitoring changes in resonance frequency that occur as a result of the overall adsorption of the bulk substance on the cantilever surface. 1,9,17 To act as a high-precision sensor, the cantilever must be covered (functionalized) with a monolayer of a molecular functional group that is speci¯c to, and capable of recognizing, a previously selected target molecule. 18,19 Functionalization involves a chemical linkage process that adheres the molecular functional groups to the cantilever surface in a layer-by-layer fashion, where functional groups interact with their respective biological target material, resulting in immobilization.…”
Section: Introductionmentioning
confidence: 99%
“…Atomic force microscopy (AFM) is a powerful tool in the study of biomolecular interactions, and can measure the binding forces at the molecular level of protein/DNA, DNA/ DNA, ligand/receptor and other biomolecule pairs. It is based on the nanomechanical cantilever sensors and microcantilever-based biosensors, which can provide rapid and sensitive in situ detection [7]. AFM has been used to study the influences of substrate stiffness on mechanical properties of cardiac myocytes and fibroblasts [8].…”
Section: Nanotechnology In Biomedical Analysis and Researchmentioning
confidence: 99%
“…These nanobiosensors can also be combined with other nanotechnologies, such as atomic force microscopy (AFM) [ 28 ], fl uorescence resonance energy transfer (FRET) [ 29 , 30 ], and DNA technology [ 31 ], to improve the quality of contrast and/or add additional properties to the sensor. Recently, a novel paper-based nanobiosensor has been developed for medical diagnostic purpose by Parolo and colleagues [ 32 ].…”
Section: Medical Diagnosticsmentioning
confidence: 99%