2019
DOI: 10.1038/s41597-019-0043-4
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Abstract: Comprehensive analysis of molecular pathology requires a collection of reference samples representing normal tissues from healthy donors. For the available limited collections of normal tissues from postmortal donors, there is a problem of data incompatibility, as different datasets generated using different experimental platforms often cannot be merged in a single panel. Here, we constructed and deposited the gene expression database of normal human tissues based on uniformly screened original sequencing data… Show more

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Cited by 76 publications
(97 citation statements)
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“…To determine whether highly expressed tissue-enriched contamination is a feature of sequencing in general, we identified two additional RNA-Seq data sets containing multiple organs/ tissues 19,23,24 . Neither study sequenced the pituitary, which is the organ with the highest levels of prolactin (PRL) expression ( Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…To determine whether highly expressed tissue-enriched contamination is a feature of sequencing in general, we identified two additional RNA-Seq data sets containing multiple organs/ tissues 19,23,24 . Neither study sequenced the pituitary, which is the organ with the highest levels of prolactin (PRL) expression ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Using the R package recount version 1.8.2, we downloaded HPA RNA-Seq data, accession ERP003613 19 . The RNA Atlas was acquired by downloading their raw RNA-seq counts from Gene Expression Omnibus (GSE120795) 23 . The HPA RNA-Seq was performed across 27 tissues and the RNA Atlas was across 20 tissues.…”
Section: Methodsmentioning
confidence: 99%
“…In this section, we use real data to show this ineffectiveness and justify the advantages of the proposed wTSD as a higher resolution method. For this purpose, we used the publicly available dataset in GEO GSE120795, also presented in Suntsova et al (2019), a comprehensive gene expression database of normal human tissues based on uniformly screened RNA-seq data. This database includes 142 tissue samples taken from 20 organs of healthy human donors of different ages, collected no later than 36 hours after death.…”
Section: Resultsmentioning
confidence: 99%
“…at various states (e.g., healthy, diseased, etc.) (Uhlen et al (2015(Uhlen et al ( , 2017; Yu et al (2015); Keen et al (2015); Mele et al (2015); Suntsova et al (2019); Sollner et al (2017)) using RNA-sequencing, a mature technology for quantifying gene transcripts in biological samples. A notable effort is the Human Protein Atlas (HPA) project (Uhlen et al (2015)), a Swedish-based program providing, among others, gene expression signatures for 37 healthy human organ tissues.…”
Section: Introductionmentioning
confidence: 99%
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