2017
DOI: 10.26605/medvet-n2-1745
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Atividade dos genes relacionados à pluripotência em ovinos

Abstract: Embriões antes da implantação possuem células pluripotentes, ou seja, células que apresentam a capacidade de se diferenciar em todos os tecidos que compõem o feto. O controle da pluripotência em nível molecular é estabelecido por diversos fatores, entre eles, os genes relacionados à pluripotência (GRPs). Estes genes contribuem para inibição do processo de diferenciação celular e manutenção da viabilidade de células pluripotentes. No entanto, apesar do crescente conhecimento sobre as funções dos GRPs em camundo… Show more

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Cited by 2 publications
(6 citation statements)
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“…Despite their contribution to the ES cell state, these genes are subject to less intense investigation during early embryogenesis (Boroviak and Nichols, 2014;Silva et al, 2017), most notably due to technical issues.…”
Section: Discussionmentioning
confidence: 99%
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“…Despite their contribution to the ES cell state, these genes are subject to less intense investigation during early embryogenesis (Boroviak and Nichols, 2014;Silva et al, 2017), most notably due to technical issues.…”
Section: Discussionmentioning
confidence: 99%
“…This initial cell differentiation event is resumed at the blastocyst stage. Outer cells become the trophoblast that ultimately gives rise to placental tissues, while inner cell mass differentiates into all cell types that make up the fetus (Moura, 2012;Boroviak and Nichols, 2014;Silva et al, 2017). All the cellular events described above account for the first week of development in mammals, while several intrinsic factors contribute to the accurate timing of developmental cues throughout this period (Pesce and Schöler, 2001;Rossant, 2011;Moura, 2012;Goissis and Cibelli, 2014).…”
Section: Introductionmentioning
confidence: 99%
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“…The expression of CMYC has also been analyzed in preimplantation embryos of ruminants species (Miles et al, 2012;Madeja et al, 2013;Singh et al, 2014;Silva et al, 2017), but its functional roles in such species remain to be described. Dosage-sensitive sex reversal, adrenal hypoplasia critical region, chromosome X, gene 1 (DAX1) DAX1 (NR0B1) was detected in oocytes and during all embryonic development of several species (Clipsham et al, 2004;Stickels et al, 2015;Moura et al, 2017;Silva et al, 2017). The characterization of mice lacking DAX1 demonstrated to be dispensable for early embryonic development (Table 1), implantation, and oogenesis (Yu et al, 1998).…”
Section: Selection Of Functionally-investigated Patfs C-mycmentioning
confidence: 99%