ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression

Li, Shuijie; Rousseau, Denis

doi:10.1007/s10863-012-9424-5

Cited by 49 publications

(41 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ATAD3A belongs to ATPase family of mitochondrial membrane proteins which is involved in mitochondrial fragmentation, cellular autophagy and ER-mitochondrial communication282937. In this study, results demonstrated that ATAD3A expression was closely associated with BmNPV infection similar with a previously reported study on HPV infection (Fig.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Baculovirus LEF-11 Hijack Host ATPase ATAD3A to Promote Virus Multiplication in Bombyx mori cells

Dong

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Research on molecular mechanisms that viruses use to regulate the host apparatus is important in virus infection control and antiviral therapy exploration. Our previous research showed that the Bombyx mori nucleopolyhedrovirus (BmNPV) LEF-11 localized to dense regions of the cell nucleus and is required for viral DNA replication. Herein, we examined the mechanism of LEF-11 on BmNPV multiplication and demonstrated that baculovirus LEF-11 interacts with Bombyx mori ATAD3A and HSPD1 (HSP60) protein. Furthermore, we showed that LEF-11 has the ability to induce and up-regulate the expression of ATAD3A and HSPD1, phenomena that were both reversed upon knockdown of lef-11. Our findings showed that ATAD3A and HSPD1 were necessary and contributed to BmNPV multiplication in Bombyx mori cells. Moreover, ATAD3A was found to directly interact with HSPD1. Interestingly, ATAD3A was required for the expression of HSPD1, while the knockdown of HSPD1 had no obvious effect on the expression level of ATAD3A. Taken together, the data presented in the current study demonstrated that baculovirus LEF-11 hijacks the host ATPase family members, ATAD3A and HSPD1, efficiently promote the multiplication of the virus. This study furthers our understanding of how baculovirus modulates energy metabolism of the host and provides a new insight into the molecular mechanisms of antiviral research.

show abstract

Section: Discussionsupporting

confidence: 90%

“…S2A and S2B)2829. HSPD1 contains a highly conserved Cpn-TCP160 functional domain and plays an essential role in protein folding (Fig.…”

Section: Resultsmentioning

confidence: 99%

Baculovirus LEF-11 Hijack Host ATPase ATAD3A to Promote Virus Multiplication in Bombyx mori cells

Dong

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…These features are known to correlate with high mutation rates, suggesting mutations in these genes may be mechanistically favored rather than selected (42). ATAD3B encodes a mitochondrial ATPase essential for embryonic development, which has been implicated in control of proliferation in cancer cell line models (43). The CNS-specific transcription factor BHLHE22 contributes to cell fate determination and proliferation, although its role in oncogenesis remains to be established (44, 45).…”

Section: Resultsmentioning

confidence: 99%

Landscape of Genomic Alterations in Pituitary Adenomas

Horowitz

Greenwald

et al. 2017

Clinical Cancer Research

105

View full text Add to dashboard Cite

Purpose Pituitary adenomas are the second most common primary brain tumor, yet their genetic profiles are incompletely understood. Experimental Design We performed whole-exome sequencing of 42 pituitary macroadenomas and matched normal DNA. These adenomas included hormonally active and inactive tumors, ones with typical or atypical histology, and ones that were primary or recurrent. Results We identified mutations, insertions/deletions, and copy number alterations. Nearly one-third of samples (29%) had chromosome arm-level copy-number alterations across large fractions of the genome. Despite such widespread genomic disruption, these tumors had few focal events, which is unusual among highly disrupted cancers. The other 71% of tumors formed a distinct molecular class, with somatic copy-number alterations involving less than 6% of the genome. Among the highly disrupted group, 75% were functional adenomas or atypical null-cell adenomas, whereas 87% of the less-disrupted group were nonfunctional adenomas. We confirmed this association between functional subtype and disruption in a validation dataset of 87 pituitary adenomas. Analysis of previously published expression data from an additional 50 adenomas showed that arm-level alterations significantly impacted transcript levels, and that the disrupted samples were characterized by expression changes associated with poor outcome in other cancers. Arm-level losses of chromosomes 1, 2, 11, and 18 were significantly recurrent. No significantly recurrent mutations were identified, suggesting no genes are altered by exonic mutations across large fractions of pituitary macroadenomas. Conclusion These data indicate that sporadic pituitary adenomas have distinct copy number profiles that associate with hormonal and histologic subtypes and influence gene expression.

show abstract

“…Despite this importance of mitochondrial CL trafficking, the molecular mechanisms involved and their regulation are poorly defined. Few proteins were reported or suspected so far to exchange lipids between mitochondrial membranes, including tBid (26), ATAD3 (27,28), and Ups1 (29,30), and to promote the necessary lipid flip-flop between inner and outer membrane leaflets, including proteins like scramblase 3 (31,32) or Bax (33).…”

mentioning

confidence: 99%

Dual Function of Mitochondrial Nm23-H4 Protein in Phosphotransfer and Intermembrane Lipid Transfer

Schlattner

Tokarska‐Schlattner

Ramirez

et al. 2013

Journal of Biological Chemistry

107

View full text Add to dashboard Cite

Background: Nm23-H4 is a mitochondrial nucleoside diphosphate kinase that binds mitochondrial membranes. Results: Nm23-H4 interaction with GTPase OPA1 provides a local GTP supply; its interaction with anionic phospholipids inhibits kinase activity but allows intermembrane cardiolipin transfer and sensitizes for apoptosis. Conclusion: Nm23-H4 is a bifunctional switch operated by cardiolipin. Significance: The cardiolipin transfer property has various implications, e.g. for lipid metabolism and apoptosis.

show abstract

ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression

Cited by 49 publications

References 28 publications

Baculovirus LEF-11 Hijack Host ATPase ATAD3A to Promote Virus Multiplication in Bombyx mori cells

Baculovirus LEF-11 Hijack Host ATPase ATAD3A to Promote Virus Multiplication in Bombyx mori cells

Landscape of Genomic Alterations in Pituitary Adenomas

Dual Function of Mitochondrial Nm23-H4 Protein in Phosphotransfer and Intermembrane Lipid Transfer

Contact Info

Product

Resources

About