volume 191, issue 10, P5124-5138 2013
DOI: 10.4049/jimmunol.1301415
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Xavier Dervillez, Huma Qureshi, Aziz A. Chentoufi, Arif A. Khan, Elizabeth Kritzer, David C. Yu, Oscar R. Diaz, Chetan Gottimukkala, Mina Kalantari, Maria C. Villacres, Vanessa M. Scarfone, Denise M. McKinney, John Sidney, Alessandro Sette et al.

Abstract: Evidence from C57BL/6 mice suggests that CD8+ T cells, specific to the immunodominant HSV-1 glycoprotein B (gB) H-2b–restricted epitope (gB498–505), protect against ocular herpes infection and disease. However, the possible role of CD8+ T cells, specific to HLA-restricted gB epitopes, in protective immunity seen in HSV-1–seropositive asymptomatic (ASYMP) healthy individuals (who have never had clinical herpes) remains to be determined. In this study, we used multiple prediction algorithms to identify 10 poten…

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