Asymmetry of Retinal Nerve Fiber Layer and Posterior Pole Asymmetry Analysis Parameters of Spectral Domain Optical Coherence Tomography in Children

Dave, Paaraj; Jethani, Jitendra; Shah, Juhi

doi:10.3109/08820538.2015.1119857

Cited by 12 publications

(24 citation statements)

References 18 publications

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“…The average RNFL thickness in our study was determined 94.46 ± 8.70 μm which is consistent with findings reported in the literature. [ 2 3 4 5 6 7 8 9 10 ] Table 6 shows OCT values of the previous studies of pediatric population with Cirrus HD-OCT, interocular symmetry and our present study as well. [ 21 22 23 24 25 26 27 28 29 ]…”

Section: Discussionmentioning

confidence: 69%

“…The RNFL measurements obtained may vary according to the OCT model used, depending on software algorithms, different models, and display scans. [ 5 6 7 8 9 10 11 12 13 14 15 16 17 ] Published literature has evidence-based proof that SD-OCT technology can determine the changes in RNFL thickness much earlier than the time-domain OCT.[ 18 19 20 21 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…The different versions of the software algorithm could be accountable for differences between values. [ 8 9 10 11 12 13 14 15 16 17 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

“…reported a positive correlation of the average RNFL thickness with refractive error in children. [ 8 9 10 19 ] Budenz et al . and Cheung et al .…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have been published in limited ethnic populations on interocular asymmetry of retinal nerve fiber layer (RNFL) in adult and pediatric healthy eyes. [ 1 2 3 4 5 6 7 8 ]…”

mentioning

confidence: 99%

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Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population

Pawar

Maheshwari

Ravindran

et al. 2017

Indian J Ophthalmol

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Purpose:To determine interocular differences in the retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters in a pediatric population using Cirrus high-definition optical coherence tomography (HD-OCT).Methods:Seventy normal Indian children aged 5–17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the RNFL and ONH by Cirrus HD-OCT. Differences between the right and left eyes were calculated and values were compared by means of a paired t-test. Subjects were also divided into two groups based on age (under or over 10 years of age). Interocular differences in RNFL and ONH parameters together with sex and age variations for these differences were determined.Results:The mean age of studied pediatric population was 11.83 ± 3.3 years (range 5–17). Average RNFL thickness was 94.46 ± 8.7 μm (± SD) (range 77–111). Differences in the average RNFL between right and left eyes were not statistically significant (P = 0.060). Superior quadrant RNFL was thicker in the left eye and temporal quadrant was thicker in the right eye. Among ONH parameters, there were no statistically significant differences in any parameters, except vertical cup-disc (CD) ratio which was significant (P = 0.007). The 2.5%–97.5% limits of asymmetry were 9 μm for average RNFL, 0.14 for average CD ratio, and 0.22 for vertical CD ratio. Mean interocular RNFL thickness differences in superior, superior nasal, and temporal superior quadrants were 10.61 (P < 0.001), 12.57 (P < 0.001), and 4.46 (P = 0.002) μm, respectively. Interocular nerve fiber layer thickness differences were not significantly correlated with sex, while only significant differences with age were observed in 12 clock hour sector analysis, mainly in nasal inferior and inferior quadrant.Conclusions:We report the degree of interocular symmetry of RNFL and ONH parameters measured by Cirrus HD-OCT in a healthy pediatric population. The normal interocular RNFL asymmetry should not exceed 9 μm and vertical CD ratio beyond 0.22 should be considered for further investigations. The physiologic asymmetry provided by this study may assist in identifying changes in RNFL thickness and ONH parameters in pediatric glaucoma and ONH disorders.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

“…The different versions of the software algorithm could be accountable for differences between values. [ 8 9 10 11 12 13 14 15 16 17 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

“…reported a positive correlation of the average RNFL thickness with refractive error in children. [ 8 9 10 19 ] Budenz et al . and Cheung et al .…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have been published in limited ethnic populations on interocular asymmetry of retinal nerve fiber layer (RNFL) in adult and pediatric healthy eyes. [ 1 2 3 4 5 6 7 8 ]…”

mentioning

confidence: 99%

See 3 more Smart Citations

Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population

Pawar

Maheshwari

Ravindran

et al. 2017

Indian J Ophthalmol

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Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants

Shen

Mangalesh

McGeehan

et al. 2021

American Journal of Ophthalmology

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Macular thickness variation and interocular symmetry by gestational age in preterm school-age children

Torres-Peña

Ortueta‐Olartecoechea²,

Muñoz-Gallego³

et al. 2022

Journal of American Association for Pediatric Ophthalmology and

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Asymmetry of Retinal Nerve Fiber Layer and Posterior Pole Asymmetry Analysis Parameters of Spectral Domain Optical Coherence Tomography in Children

Abstract: The normal interocular RNFL and PPAA macular thickness asymmetry should not exceed 12.5 microns and 21 microns, respectively. Similar intraocular limits for superior-inferior asymmetry should not exceed 40 and 38 microns, respectively.

Cited by 12 publications

References 18 publications

Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population

Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population

Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants

Macular thickness variation and interocular symmetry by gestational age in preterm school-age children

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