Asymmetry and Microstructure of Temporal-Suppression Patterns in Basilar-Membrane Responses to Clicks: Relation to Tonal Suppression and Traveling-Wave Dispersion

Charaziak, Karolina K.; Dong, Wei; Altoè, Alessandro; Shera, Christopher A.

doi:10.1007/s10162-020-00747-2

Cited by 10 publications

(2 citation statements)

References 65 publications

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“…Stimuli were generated, delivered, and controlled through an iMac computer (Apple, CA, USA) running Auditory Research Lab Audio Software (ARLas v4.2017 82 ) on MATLAB. The iMac was interfaced with an external sound card (Fireface UFX+; RME, Germany) via Thunderbolt for analog-to-digital-to-analog conversion at a sampling rate of 96 kHz.…”

Section: Methodsmentioning

confidence: 99%

Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition

Boothalingam

Peterson

Powell

et al. 2023

Sci Rep

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Feedback networks in the brain regulate downstream auditory function as peripheral as the cochlea. However, the upstream neural consequences of this peripheral regulation are less understood. For instance, the medial olivocochlear reflex (MOCR) in the brainstem causes putative attenuation of responses generated in the cochlea and cortex, but those generated in the brainstem are perplexingly unaffected. Based on known neural circuitry, we hypothesized that the inhibition of peripheral input is compensated for by positive feedback in the brainstem over time. We predicted that the inhibition could be captured at the brainstem with shorter (1.5 s) than previously employed long duration (240 s) stimuli where this inhibition is likely compensated for. Results from 16 normal-hearing human listeners support our hypothesis in that when the MOCR is activated, there is a robust reduction of responses generated at the periphery, brainstem, and cortex for short-duration stimuli. Such inhibition at the brainstem, however, diminishes for long-duration stimuli suggesting some compensatory mechanisms at play. Our findings provide a novel non-invasive window into potential gain compensation mechanisms in the brainstem that may have implications for auditory disorders such as tinnitus. Our methodology will be useful in the evaluation of efferent function in individuals with hearing loss.

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Section: Methodsmentioning

confidence: 99%

Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition

Boothalingam

Peterson

Powell

et al. 2023

Sci Rep

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“…All stimuli were digitally generated in MATLAB (v2016b; Mathworks, MA, USA) at a sampling rate of 96 kHz and a bit depth of 24. Similar to Boothalingam et al (2018), clicks were generated in the frequency domain using a recursive exponential filter (Zweig and Shera, 1995;Charaziak et al, 2020) for band-limiting the click between 0.8 and 6 kHz (∼108 µs long). Bandpass clicks were used to focus the stimulus energy in the frequency regions where the MOCR is most prominent (Lilaonitkul and Guinan, 2012;Zhao and Dhar, 2012).…”

Section: Stimulus Generationmentioning

confidence: 99%

A Time-Course-Based Estimation of the Human Medial Olivocochlear Reflex Function Using Clicks

et al. 2021

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The auditory efferent system, especially the medial olivocochlear reflex (MOCR), is implicated in both typical auditory processing and in auditory disorders in animal models. Despite the significant strides in both basic and translational research on the MOCR, its clinical applicability remains under-utilized in humans due to the lack of a recommended clinical method. Conventional tests employ broadband noise in one ear while monitoring change in otoacoustic emissions (OAEs) in the other ear to index efferent activity. These methods, (1) can only assay the contralateral MOCR pathway and (2) are unable to extract the kinetics of the reflexes. We have developed a method that re-purposes the same OAE-evoking click-train to also concurrently elicit bilateral MOCR activity. Data from click-train presentations at 80 dB peSPL at 62.5 Hz in 13 young normal-hearing adults demonstrate the feasibility of our method. Mean MOCR magnitude (1.7 dB) and activation time-constant (0.2 s) are consistent with prior MOCR reports. The data also suggest several advantages of this method including, (1) the ability to monitor MEMR, (2) obtain both magnitude and kinetics (time constants) of the MOCR, (3) visual and statistical confirmation of MOCR activation.

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Reflection-Source Emissions Evoked with Clicks and Frequency Sweeps: Comparisons Across Levels

Charaziak

Shera

2021

JARO

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Asymmetry and Microstructure of Temporal-Suppression Patterns in Basilar-Membrane Responses to Clicks: Relation to Tonal Suppression and Traveling-Wave Dispersion

Cited by 10 publications

References 65 publications

Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition

Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition

A Time-Course-Based Estimation of the Human Medial Olivocochlear Reflex Function Using Clicks

Reflection-Source Emissions Evoked with Clicks and Frequency Sweeps: Comparisons Across Levels

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