2003
DOI: 10.1021/cr020027w
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Abstract: Professor Trost's research interests include the invention and development of new synthetic reactions largely based upon catalysis using transition-metal complexes and their use to define strategies that result in the total synthesis of complex molecules largely of biological importance. Matthew L. Crawley was born in Suffern, NY, in 1976. He obtained his B.A. degree from Williams College with a double major in political economy and chemistry under the guidance of Professor J. Hodge Markgraf. In 1998 he starte… Show more

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Cited by 2,575 publications
(798 citation statements)
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“…[26,27] To increase the synthetic utility and practicability of these effective ligands in asymmetric catalysis, herein, we report the facile synthesis of soluble polymer MeO-PEG supported ferrocenyloxazoline-derived chiral N,P and N,S ligands ( Figure 1) and their applications in 1,3-dipolar cycloaddition reaction and asymmetric allylic substitution reaction. [28,29] …”
Section: Introductionmentioning
confidence: 99%
“…[26,27] To increase the synthetic utility and practicability of these effective ligands in asymmetric catalysis, herein, we report the facile synthesis of soluble polymer MeO-PEG supported ferrocenyloxazoline-derived chiral N,P and N,S ligands ( Figure 1) and their applications in 1,3-dipolar cycloaddition reaction and asymmetric allylic substitution reaction. [28,29] …”
Section: Introductionmentioning
confidence: 99%
“…alkoxides; allylic substitution; asymmetric synthesis; iridium; metallacycle Intermolecular, enantioselective allylic substitution with alcohols [1,2] remains an undeveloped catalytic process. Few reports have been published that describe the intermolecular allylation of aliphatic alcohols with high yield and enantioselectivity, [3] and the most selective of these systems has required copper additives.…”
Section: Introductionmentioning
confidence: 99%
“…
Keywordsalkoxides; allylic substitution; asymmetric synthesis; iridium; metallacycle Intermolecular, enantioselective allylic substitution with alcohols [1,2] remains an undeveloped catalytic process. Few reports have been published that describe the intermolecular allylation of aliphatic alcohols with high yield and enantioselectivity, [3] and the most selective of these systems has required copper additives.

[4] The large number of α chiral ethers and oxygen heterocycles in natural products and pharmaceutical candidates makes enantioselective routes to these materials important.

This transformation has been difficult because alcohols are poor nucleophiles for allylic substitution, and the high basicity of alkoxides can induce elimination processes and catalyst deactivation.

…”
mentioning
confidence: 99%
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