Asymmetric Syntheses with the Aid of Homogeneous Transition Metal Catalysts

Abstract

The progress made in the field of homogeneous catalysis during the last five to six years has led, inter alia, to the development of highly selective catalysts for asymmetric syntheses. Homogeneous asymmetric hydrogenation, using well defined transition metal catalysts, may be achieved with optical yields of 85 to 90% or more. Catalytic reactions, in which the chiral centers are generated by C-C bond formation, can result in optical yields of 70 to 80 YO. The hydrogenation catalysts consist primarily of rhodiu…