volume 19, issue 4, P250-255 1996
DOI: 10.1016/0141-0229(95)00242-1
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Katz Lorraine, Steve King, Randolph Greasham, Michel Chartrain

Abstract: A microbial screen identified the yeast Rhodotorula rubra MY 2169 as a suitable biocatalyst for the asymmetric bioreduction of a ketosulfone (5,6 dihydro-6(s)-propyl-4H-thieno[2,3b] thiopyran-4-one-7,7-dioxide) to the corresponding trans-hydroxysulfone. This synthesizer is a precursor to the carbonic anhydrase inhibitor L-685,393, a new drug candidate targeted for the treatment of ocular glaucoma. Process development studies revealed that the rate of bioreduction was sensitive to temperature, pH, solvent conce…

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